Results 211 to 220 of about 595,429 (265)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Addressing Data Quality Challenges in Lung Cancer Data Within the Observational Medical Outcomes Partnership Common Data Model: Observational Study. [PDF]

J Med Internet Res
Declerck J, Deschepper M, Colpaert K, Kalra D, Coorevits P.   +4 more
europepmc   +1 more source

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Mapping the backbone of science

Scientometrics, 2005
This paper presents a new map representing the structure of all of science, based on journal articles, including both the natural and social sciences. Similar to cartographic maps of our world, the map of science provides a bird’s eye view of today’s scientific landscape.
Kevin W. Boyack, Richard Klavans, Katy Börner   +2 more
openaire   +1 more source

Metro maps of science

Proceedings of the 18th ACM SIGKDD international conference on Knowledge discovery and data mining, 2012
As the number of scientific publications soars, even the most enthusiastic reader can have trouble staying on top of the evolving literature. It is easy to focus on a narrow aspect of one's field and lose track of the big picture. Information overload is indeed a major challenge for scientists today, and is especially daunting for new investigators ...
Dafna Shahaf, Carlos Guestrin, Eric Horvitz   +2 more
openaire   +1 more source

Comparison of the Maps of Science

Scientometrics, 2000
The aim of this article is to describe some methods of comparison of maps of science and to show possibilities that these methods give for further research in this interesting area.
openaire   +1 more source