Results 91 to 100 of about 20,000,822 (310)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

A FAIR Data Ecosystem for Science of Science. [PDF]

open access: yesProc Assoc Inf Sci Technol, 2023
Qin J   +4 more
europepmc   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Editorial: Women in science-Regulatory science 2021. [PDF]

open access: yesFront Med (Lausanne), 2023
Thomsen MDT, Knudsen LE.
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Proceedings of the Arizona-Nevada Academy of Science, Volume 54 (2019)

open access: yes, 2019
63rd Annual Meeting / April 6, 2019 / Arizona Western College and University of Arizona / Yuma, AZThis volume is part of the Arizona-Nevada Academy of Science collections.
Arizona-Nevada Academy of Science
core  

Critical realist philosophy for science [PDF]

open access: yes, 2002
i, 95 leaves ; 28 cm.This paper considers the philosophy of science that is central to Critical Realism (CR). Following a discussion of the foundational transcendental arguments of the movement, it reviews stratification, emergence, and the possibility ...
University of Lethbridge. Faculty of Arts and Science   +1 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Reklama: Filosofický časopis

open access: yesTeorie vědy, 2020
Advertisement: The Philosophical Journal (Filosofický časopis)
Teorie vědy / Theory of Science
doaj  

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