Results 71 to 80 of about 37,181,712 (276)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

One Health Education Nexus: enhancing synergy among science-, school-, and teacher education beyond academic silos. [PDF]

Front Public Health, 2023
Hobusch U, Scheuch M, Heuckmann B, Hodžić A, Hobusch GM, Rammel C, Pfeffer A, Lengauer V, Froehlich DE.   +8 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Strengthening Capacity for Implementation Research Amid COVID-19 Pandemic: Learnings From the Global Alliance for Chronic Diseases Implementation Science School. [PDF]

Int J Public Health, 2022
Aziz Z, Haregu T, Kyobutungi C, Yan L, Irazola V, Absetz P, Bandurek I, Roberts M, Vedanthan R, Folkes S, Cao Y, Wen Y, Aung MN, Danhieux K, Desloge A, Oldenburg B.   +15 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

CONDILLAC E O ENSINO DE CIÊNCIAS: QUE RELAÇÕES PODEMOS ENCONTRAR AINDA HOJE?

Ensaio Pesquisa em Educação em Ciências
Resumo: Via de regra, pouco nos ocupamos em pensar as epistemologias que sustentam e orientam as ações em sala de aula. Há um relativo consenso de que os livros didáticos desempenham um papel importante na definição dos currículos.
Maria Emilia Caixeta
doaj   +1 more source

Importance of pre-school science education

SHS Web of Conferences, 2017
Considering this aspect of the study, the objective of the study is determining the importance of science education in pre-school period. In this research, two open-ended questions were asked to the prospective teachers. In these questions, the focus was
Kaçan Sibel Demir, Çelikler Dilek
doaj   +1 more source

Science and science education: Ideas and practices of science teachers in high school in Cambina/Angola

Amazônia, 2011
In this article, we present an outline of a qualitative research approach in narrative, developed with high school science teachers in the province of Cabinda, Angola.
Juliana Lando Canga, Terezinha Valim Oliver Gonçalves, Ruth Gabriel Canga Buza   +2 more
doaj   +1 more source