Results 101 to 110 of about 42,356,875 (310)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Symposium of the Arizona-Nevada Academy of Science (1973)

open access: yes, 1973
SEVENTEENTH ANNUAL MEETING / May 5, 1973 / Joint Meeting with the Pacific Division of the American Association for the Advancement of Science / University of Arizona / Tucson, ArizonaThis volume is part of the Arizona-Nevada Academy of Science ...
Arizona-Nevada Academy of Science
core  

A sacrificial magnet concept for field dependent surface science studies. [PDF]

open access: yesMethodsX, 2023
Liu D   +5 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

European Studies in Philosophy of Science (ESPS) [PDF]

open access: yes
Book Series: European Studies in Philosophy of Science (ESPS) Editors: Dennis Dieks; Maria Carla Galavotti; Wenceslao J. Gonzalez This new series results from the synergy of EPSA - European Philosophy of Science Association - and PSE - Philosophy ...
GALAVOTTI, MARIA CARLA   +2 more
core   +1 more source

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