Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
A Scoping Review of Implementation Science Studies in the Field of Traumatic Brain Injury: State of the Science and Future Directions. [PDF]
Hyzak KA +5 more
europepmc +1 more source
Discerning protein pools by selective staining with self‐labeling tags
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
La fabrique de la géographie urbaine critique et radicale
Cécile Gintrac
doaj +1 more source
Surface science studies of the coverage dependent adsorption of methyl acetate and methyl propanoate on graphite. [PDF]
Fulker JE, Brown WA.
europepmc +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Perspective (Institute for Christian Studies)
Tricia and Benjamin Groenewold write from Lithuania. -- Vocational wayfinding. -- Where in the world have your gifts made an impact? -- Congratulations to five Master's and two PhD graduates.
Groenewold, Benjamin +2 more
core
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Science and Technology Studies: Exploring the Knowledge Base [PDF]
Science and Technology Studies (STS) is one of a number of new research fields to emerge over the last four or five decades. This paper attempts to identify its core academic contributions using the references that are most cited by the authors of ...
Paul Nightingale +2 more
core
Unveiling Bias: Examining the Influence of Positive Results on Ergogenic Aids in Published Sports Science Studies. [PDF]
Marocolo M +8 more
europepmc +1 more source

