Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Invisible Wounds: Psychological and Neurological Injuries Confront a New Generation of Veterans [PDF]
As early as 1919, doctors began to track a psychological condition among combat veterans of World War I known as "shell shock." Veterans were suffering from symptoms such as fatigue and anxiety, but science could offer little in the way of effective ...
Erin Mulhall, Vanessa Williamson
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Traditional Revolt against the Modern Science (Philosophy in the Inter-war Period)
Marek Jedliński
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In Times of Health Crisis and War, Science and Education are More Important Than Ever [PDF]
Martin Björck +2 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Tracing Cold War in Post-Modern Management's Hot Issues [PDF]
Tracing Cold War in post-modern managerial science and ideology one encounters hot issues linking contemporary liberal dogmas and romanticized view of organizational leadership to the dismantling of a welfare state disguised as a liberation of an ...
Magala, S.J.
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Battle of Vellinghausen: Lessons Learnt? A Study of the British army in the closing stages of the Seven Years War in Western Europe as studied through the Battle of Vellinghausen [PDF]
This is a study of the British military actions in Western Germany during the Seven Years War, investigating the army’s ability in combat and analysing its improvements through the case study of the Battle of Vellinghausen.
Dodson, Samuel
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Antes del Arte in Spain (1968–1969): Merging Art, Science and Politics in the Heat of the Cold War [PDF]
Paula Barreiro López
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Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
The Missing Basics & Other Philosophical Reflections for the Transformation of Engineering Education [PDF]
The paper starts by reflecting on what senior engineering students don't know how to do when they confront a real-world project in an industrially sponsored senior design project. Seven, largely qualitatively, skills are found to be lacking: questioning,
Goldberg, David E.
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