Results 131 to 140 of about 7,192,706 (393)

Trichostatin A attenuates E.coli-induced inflammation by modulating CD4+T cell homeostasis

open access: yes陆军军医大学学报
Objective To investigate the role of trichostatin A (TSA) in regulating CD4+T cell subpopulations during Escherichia coli (E.coli) inflammatory infections. Methods Male mice (8 weeks old, weighing 22~25 g) were randomly divided into 3 groups (n=16): a
XIA Yu, YU Jing, CHEN Daiqi, CHEN Daiqi
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Book review: a lab of one's own: science and suffrage in the First World War by Patricia Fara [PDF]

open access: yes, 2018
In A Lab of One's Own: Science and Suffrage in the First World War, Patricia Fara follows the trajectories of women scientists during World War One, describing their struggles in academia and laboratories in tandem with the battle for the vote and the ...
Chassonnery-Zaïgouche, Cléo
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Regionalism,Reconstitution and Theses for Designing a Strategy for Economic Growth and Development of Slavonia and Baranya [PDF]

open access: yes
Intensive ageing of population as well as its overall wrong educational orientation send a strong message that economic regression indicates that population and economy are caught in a vicious circle of a crisis, since under such circumstances people ...
Ivana Barkovic, Nedeljko Bosanac
core  

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

The British sciences and the Great War

open access: yesMètode Science Studies Journal: Annual Review
The history of the relations of science and war in the United Kingdom during the Great War has been the subject of much mythologising, by scientists and by historians. Those myths need to be understood, not ignored. Contrary to those myths, the UK had a
David Edgerton
doaj   +1 more source

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