Results 251 to 260 of about 175,781 (305)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source
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The Science of War

2021
Lieutenant General Nikolai Nikolayevich Golovin (1875–1944) is considered one of the leaders of the Russian émigrés in the interwar period. During this time, he published extensively, focusing on military history, strategy and military science. Considered by present-day Russian strategists as a distinguished Russian military scientist, Golovin mainly ...
exaly   +2 more sources

Putting pragmatism to work in the Cold War: Science, technology, and politics in the writings of James B. Conant [PDF]

open access: yesStudies in History and Philosophy of Science Part A, 2011
This paper examines James Conant’s pragmatic theory of science – a theory that has been neglected by most commentators on the history of 20th-century philosophy of science – and it argues that this theory occupied an important place in Conant’s strategic
Justin Biddle
exaly   +2 more sources

Science and War [PDF]

open access: yes, 2022
MP4 video, Size: 2.73GB; Duration: 1:32Please cite as: Academy of Science of South Africa (ASSAf), (2022). Science and War. [Online] Available at: http://hdl.handle.net/20.500.11911/235In times of war, scientists ask themselves what their role can and ...
Royal Society of South Africa (RSSA)   +1 more
openaire   +2 more sources

War on Science Agencies

Scientific American, 2018
The articles the impact of science-related cuts proposed by the US White Administration under President Donald Trump. It talks about how federal science agencies remain understaffed and lose critical expertise and capacity, like the Environmental Protection Agency, Centers for Disease Control and Prevention, and National Aeronautics and Space ...
Andrew A, Rosenberg, Kathleen, Rest
openaire   +2 more sources

The Science Wars: Responses to a Marriage Failed

Social Text, 1996
Les « guerres de la science », ou l'attaque defensive contre la « fuite de la science et de la raison », sont dirigees contre des etudes recentes qui assimilent la science a une activite influencee par les forces sociales et politiques. L'interet intellectuel pour la science de la part de non-scientifiques s'est beaucoup developpe depuis plus de vingt ...
openaire   +1 more source

The Left's War on Science

Scientific American, 2013
The author discusses the effects of politics on science, arguing that both liberals and conservatives can be hostile to various scientific facts. He notes that a large percentage of liberals believe in creationism and deny global warming, as well as dispute theories of human brain evolution and evolutionary psychology.
openaire   +2 more sources

The Science Wars

Minerva, 2007
The so-called 'Science Wars' is a puzzling, largely American cultural phenomenon. The phrase gained prominence in 1996, when a rather obscure cultural studies journal called Social Text devoted an entire issue to critiques of Paul R. Gross and Norman Leavitt's controversial book, Higher Superstition: The Academic Left and its Quarrels with Science.1 ...
openaire   +1 more source

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