Results 131 to 140 of about 16,742,935 (285)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Five minutes with Conor Gearty: “It is very frustrating that my online project The Rights’ Future counts for nothing in my professional life. It is not teaching; it is not scholarly research; and it does not have impact” [PDF]
, 2012 Following the success of his collaborative online project, The Rights’ Future, Conor Gearty tells us how interactive blogging became his most enjoyable academic work to date and how creating his online presence has become a mountain with no ...
Blog Admin, Impact of Social Sciences, +1 more
core
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Development of science LKPD based on inquiry training on HOTS-science literacy skills
Inovasi KurikulumLKPD circulating in schools mostly does not contain experiments, demonstrations or discussions. This research aims to produce worksheets for students as teaching materials used in the science learning process, thereby creating maximal learning activities
Dini Rozali +2 more
doaj +1 more source
Five minutes with Bora Zivkovic: “The blog is a way for me to promote young and new voices, that’s why they call me The Blogfather!” [PDF]
, 2012 One of the best known science writers and bloggers in the online world, Bora Zivkovic is the chief editor and community manager of the Scientific American blogs network.
Blog Admin, Impact of Social Sciences, +1 more
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The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Life sciences accomplishments [PDF]
From its inception, the main charter of Life Sciences has been to define biomedical requirements for the design and development of spacecraft systems and to participate in NASA's scientific exploration of the universe.
core +1 more source
Historical Epistemology Meets the Human Sciences [PDF]
, 2011 The paper addresses recent developments in historical epistemology, traces the main inspirational sources that feed this approach, and suggests a possible agenda for closer approximation between historical epistemology and the human sciences in studying ...
Balon, Jan, Dvořák, Tomáš
core
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source