Results 141 to 150 of about 5,072,705 (358)

Çağdaş Bir Din Eğitimi Teorisi Olarak Çoğulcu Din Eğitimi Modeli Batı Örneği

open access: yesDini Araştırmalar, 2015
One of the most striking features of our century is its pluralistic character This situation is valid for both the west and the east. Although the west has mostly a Christian population, it is a fact that millions of people who have different faiths and ...
Mustafa Köylü
doaj  

The Thayer Method: Student Active Learning with Positive Results [PDF]

open access: yes, 2000
Graduation from West Point requires successful completion of four courses in the mathematical sciences. These core mathematics courses include topics in discrete dynamical systems, differential and integral calculus (single variable and multivariable ...
Connors, E.
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

The use of learning management platforms in school context - a national study [PDF]

open access: yes, 2008
This report results from a national study carried out under the Project “Educational application of learning management platforms”, supported and funded by the Computers, Networks, and Internet in Schools department of the Portuguese Ministry of ...
Matos, J.F.   +3 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

The Scientific Revolution of Thomas Kuhn and Their Relevances for Humanization of Islamic Law [PDF]

open access: yes, 2016
This paper tries to explore the views of Thomas Kuhn that science is moving through the stages that will culminate in normal conditions and then "rot" because it has been replaced by science or new paradigm. So next.
Kamal, M. A. (Muhamad)
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Road map of Iran’s internationalization of medical sciences education: Experience of Isfahan University of medical sciences [PDF]

open access: yesمجله ایرانی آموزش در علوم پزشکی, 2017
Road map of Iran’s internationalization of medical sciences education: Experience of Isfahan University of medical ...
Habib Rezaei   +4 more
doaj  

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