Results 31 to 40 of about 977,510 (303)

Absortive capacity: Overview of the evolutionary path of research networks (1976-2020)

Contextus, 2021
This study analyzes the evolution of scientific publications on absorptive capacity (Absorptive Capacity -ACAP) between 1976-2020 to construct a research panorama.
Karina Teixeira Lima, Vinicius Farias Moreira   +1 more
doaj   +1 more source

Japan strives to improve its scientific capacity

, 2022
The world’s leading science magazine reports Japan’s effort to improve its scientific stature, with a bold capital expenditure of US$2.3 billion on a small group of leading ...
openaire   +1 more source

Addressing NCDs through research and capacity building in LMICs: lessons learned from tobacco control [PDF]

Global Health Action, 2016
Confronting the global non-communicable diseases (NCDs) crisis requires a critical mass of scientists who are well versed in regional health problems and understand the cultural, social, economic, and political contexts that influence the effectiveness ...
Rachel Sturke, Susan Vorkoper, Kalina Duncan, Marya Levintova, Mark Parascondola   +4 more
doaj   +1 more source

Science Collaboration for Capacity Building: Advancing Technology Transfer Through a Treaty for Biodiversity Beyond National Jurisdiction

Frontiers in Marine Science, 2020
Marine technology transfer and capacity building are key elements in the development of a historic new agreement for the conservation and sustainable use of marine biodiversity in areas beyond national jurisdiction (BBNJ agreement) under the United ...
Harriet Harden-Davies, Paul Snelgrove
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Developing scientific capacity in the Global South [PDF]

, 2019
This thesis aimed to identify concrete ways to develop scientific capacity in the Global South, and in linking those research efforts to national socio-economic objectives. Methodologically, the different chapters apply an array of econometric, bibliometric, text mining and social network analysis techniques applied to four different datasets.
openaire   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source