Results 71 to 80 of about 5,647,510 (295)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
On the impact of quantum computing technology on future developments in high-performance scientific computing [PDF]
Ethics and Information Technology, 2017 Quantum computing technologies have become a hot topic in academia and industry receiving much attention and financial support from all sides. Building a quantum computer that can be used practically is in itself an outstanding challenge that has become ...
M. Möller, C. Vuik
semanticscholar +1 more source
Hand Motion Capture from a 3D Leap Motion Controller for a Musculoskeletal Dynamic Simulation
Sensors, 2021 The AnyBody Modeling System™ (AMS) is a musculoskeletal software simulation solution using inverse dynamics analysis. It enables the determination of muscle and joint forces for a given bodily motion.
Robin Fonk +3 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
UNWRAPPING HIGHLY-DETAILED 3D MESHES OF ROTATIONALLY SYMMETRIC MAN-MADE OBJECTS [PDF]
ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2013 Rotationally symmetric objects commonly occur at archæological finds. Instead of creating 2D images for documentation purposes by manual drawing or photographic methods, we propose a method based on digitally colored surface models that are acquired by ...
B. Rieck, H. Mara, S. Krömker
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Journal of Open Source Software, 2018 MLxtend is a library that implements a variety of core algorithms and utilities for machine learning and data mining. The primary goal of MLxtend is to make commonly used tools accessible to researchers in academia and data scientists in industries ...
S. Raschka
semanticscholar +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Nature CommunicationsPeptide O-glycosylation relies on the coordinated action of glycosyltransferases across the endoplasmic reticulum (ER) and Golgi apparatus. However, the molecular mechanisms driving aberrant glycosylation in cancer remain poorly understood.
Abdullateef Nashed +3 more
doaj +1 more source