Results 71 to 80 of about 909,869 (300)
Bioactivity studies on Zanthoxylum budrunga wall (Rutaceae) root bark
Clinical Phytoscience, 2018 Background The root-bark of the medicinally important plant Zanthoxylum budrunga (ZBRB) brooks a variety of uses in ethnobotanical and ethnomedicinal practice in Bangladesh and thus demands biological investigation to reveal its therapeutic potentiality.
Md Khirul Islam +6 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The Agency of Scientific Disciplines
, 2023 This paper discusses the agency of scientific disciplines and reconstructs it as representative agency. In the case of disciplinary representative agency, individual and organizational actors are committed to the reflexive interests of a discipline and act on their behalf.
openaire +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Natural Product Communications, 2010 Cellulose was extracted from the roots, stems and stem tips of Salicornia brachiata Roxb. Each crude cellulose sample obtained was fractionated into α- and β-celluloses. The yields of crude cellulose from the stems and stem tips were greatest and lowest,
Naresh D Sanandiya +3 more
doaj +1 more source
PENDIDIKAN IPS SEBAGAI "SYNTHETIC DISCIPLINE": KAJIAN EPISTEMOLOGIS ATAS PEMIKIRAN NU'MAN SOMANTRI
Cakrawala Pendidikan: Jurnal Ilmiah Pendidikan, 2015 Abstrak: Pemikiran seorang atau kelompok pakar merupakan bagian integral dalam dinamika sebuah disiplin ilmu, dan kajian terhadapnya telah menjadi concern dalam berbagai disiplin ilmu.
Mohammad Imam Farisi, Abdul Malik
doaj +1 more source
, 2014 Genetics and the biological sciences are the two contemporary scientific fields most readily called to mind in thinking about science and eugenics. Yet the history of another discipline, psychology, is enmeshed more intricately with eugenics than are the
Wilson, Robert A.
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source