Results 41 to 50 of about 728,635 (308)

THE ISSUES OF LEGAL REGULATION OF RATIONAL ENVIRONMENTAL MANAGEMENT ON AGRICULTURAL, FORESTRY AND WATER FUND LANDS

Правовое государство: теория и практика
The relevance of the study is due to the need to improve the legal regulation of the modern process of involvement in the civil turnover of agricultural land, recreational coastal zones and forestry fund, which are the place of attraction for ...
VLADIMIROV Igor Aleksandrovich, MULLAGALEEV Ilnur Afruzovich   +1 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Development of single-industry towns as a factor of economic and regional growth [PDF]

E3S Web of Conferences, 2020
Single-industry towns occupy a special place in the system of regional economic development of Russia. To date, domestic practice has accumulated significant experience in the management of mono-profile areas.
Rubtsov Gennadiy, Litvinenko Aleksandr
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Totalidades documentales y percepción del profesional de la información: El caso de la contextualidad compleja [PDF]

, 2013
"Totality of information recorded in documents, and the perception of the professional of information: The case of the complex contextuality." Abstract: New alternatives of understanding, production of ideas and recent scientific and technological ...
de-la-Cantera Pérez, Ada de Jesús
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

EURAD − the European Joint Programme for research on radioactive waste management between EU members states national programmes

EPJ Nuclear Sciences & Technologies, 2020
For more than 40 years, considerable scientific and technical knowledge has been acquired in Europe in the field of radioactive waste management, both for near-surface disposal and geological disposal.
Garcia Marie, Beattie Tara, Schumacher Stéphan   +2 more
doaj   +1 more source

Seeing 'REDD'?: Forests, Climate Change Mitigation and the Rights of Indigenous Peoples [PDF]

, 2008
Examines proposals for reducing emissions from deforestation and forest degradation (REDD) and their failure to protect indigenous peoples' rights or to address forest governance problems.
Tom Griffiths
core  

A Project Portfolio Management model adapted to non-profit organizations [PDF]

, 2016
As they strive towards greater professionalism in carrying out their activities, non-profit organizations (NPOs) have begun paying attention to project management.
de Freitas, Henrique M R, Lacerda, Fabrício Martins, Martens, Cristina Dai Prá   +2 more
core   +3 more sources