Results 61 to 70 of about 728,635 (308)

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Analysis of nursing management papers published in 12 nursing core journals in China from 2015 to 2017

open access: yesHuli yanjiu, 2019
ObjectiveTo understand the research status,research hotspot and development trend in the field of nursing management in recent years,and to provide a reference for the further improvement of nursing management system.MethodsWith Wanfang database and CNKI
CHENG Jinlian   +4 more
doaj  

Economic evaluation of LIFE methodology [PDF]

open access: yes, 2007
Background: The LIFE project (Lifecycle Information For E-Literature) was carried out during 2004-2006 by a consortium consisting of The British Library and University College London Library Services .
Björk, B.-C.
core  

CGIAR Research Program on Forests, Trees and Agroforestry - Plan of Work and Budget 2020 [PDF]

open access: yes, 2020
There were no significant changes in 2019 to FTA’s theory of change1. FTA plans all its work on the basis of its operational priorities. These, in turn, focusresearch towards major development demands and knowledge gaps, orienting FTA towards the ...
CGIAR Research Program on Forests, Trees and Agroforestry
core  

Innovative Regulatory Frameworks Promoting Green Economy for Sustainable Development and Poverty Eradication in Europe [PDF]

open access: yes, 2013
The political Rio 20 Declaration challenges lawyers and legal professionals around the world to think creatively about the legal preparedness for the green economy.
Gehring, Markus, Kent, Avidan
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Anticipating trade-offs and promoting synergies between small-scale fisheries and aquaculture to improve social, economic, and ecological outcomes

open access: yesnpj Ocean Sustainability
Blue food systems are crucial for meeting global social and environmental goals. Both small-scale marine fisheries (SSFs) and aquaculture contribute to these goals, with SSFs supporting hundreds of millions of people and aquaculture currently expanding ...
Elizabeth J. Mansfield   +17 more
doaj   +1 more source

The Workforce Needs of New Jersey's Pharmaceutical and Medical Technology Industry [PDF]

open access: yes, 2007
This report is based on an online survey conducted in spring 2006 of pharmaceutical and medical technology companies in New Jersey. It identifies the current and future workforce needs of the pharmaceutical and medical technology industry in New ...

core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

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