Results 91 to 100 of about 654,141 (288)
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Клиническая и экспериментальная тиреоидология, 2017 Along with globalization and the development of the Internet, new phenomenon have appeared and multiplied: international open access (OA) scientific journals in which manuscripts can be published for a fee. It should be stipulated that the bulk of the OA
Grigory A. Gerasimov
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Portability of Scientific Manuscripts and Reviewers’ Comments
Journal of Clinical Interventional Radiology ISVIR, 2022 Shoban Haridass +2 more
doaj +1 more source
Reviewing scientific manuscripts in 2023: is it (still) worth the time? [PDF]
EuroIntervention, 2023 Amabile N, Stefanini G.
europepmc +1 more source
The final report for progress during the period from 15 Nov. 1988 to 14 Nov. 1991 is presented. Research on methods for analysis of sound propagation through the atmosphere and on results obtained from application of our methods are summarized.
Jacobson, M. J. +2 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Hebrew Medical Manuscripts in Portugal between the 13th and the 16th centuries [PDF]
Revista da Faculdade de Letras. Série de História, 2016 Portugal has been an important Jewish intellectual center in the Middle Ages and during the 16th century. The Hebrew manuscripts that survive from this period testify to the prosperity of the Jewish community in different fields such as philosophy ...
Irina Visan
doaj