Results 61 to 70 of about 654,141 (288)

The Miracle of Peer Review and Development in Science: An Agent-Based Model [PDF]

, 2016
It is not easy to rationalize how peer review, as the current grassroots of science, can work based on voluntary contributions of reviewers. There is no rationale to write impartial and thorough evaluations.
Righi, Simone, Takács, Károly
core   +5 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A Beginner's Guide to Writing Scientific Manuscripts

Precision Nanomedicine
Publishing articles is an existential need for every scientist. All scientific journal websites have numerous pages describing the requirements for a manuscript. However, how to satisfy those requirements is not explained, which is a real problem for a
Lajos Balogh
doaj   +1 more source

Exploring manuscripts: sharing ancient wisdoms across the semantic web [PDF]

, 2012
Recent work in digital humanities has seen researchers in-creasingly producing online editions of texts and manuscripts, particularly in adoption of the TEI XML format for online publishing.
Hedges, Mark, Jordanous, Anna, Lawrence, K Faith, Tupman, Charlotte   +3 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Digistylus - An Online Information System For Palaeography Teaching and Research [PDF]

, 2009
This paper starts by describing the experiences the authors recently had with online information systems for teaching and research in palaeography. The study also considers the differences in the students' access to the site "Teaching Materials for Latin
Cartelli, Antonio, Palma, Marco
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Enforcing public data archiving policies in academic publishing: A study of ecology journals

, 2018
To improve the quality and efficiency of research, groups within the scientific community seek to exploit the value of data sharing. Funders, institutions, and specialist organizations are developing and implementing strategies to encourage or mandate ...
Boettiger, Carl, Katz, Daniel S., Ram, Karthik, Sholler, Dan   +3 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Formatting Open Science: agilely creating multiple document formats for academic manuscripts with Pandoc Scholar [PDF]

PeerJ Computer Science, 2017
The timely publication of scientific results is essential for dynamic advances in science. The ubiquitous availability of computers which are connected to a global network made the rapid and low-cost distribution of information through electronic ...
Albert Krewinkel, Robert Winkler
doaj   +2 more sources