Results 81 to 90 of about 400,799 (288)
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Tantangan utama preservasi naskah kuno berbasis digitisasi
Berkala Ilmu Perpustakaan dan InformasiIntroduction. This research aims to determine the main challenges in preserving ancient manuscripts based on digitization. Research methods. This study used descriptive qualitative method.
Testiani Makmur +3 more
doaj +1 more source
Learning from Jesus’ Wife: What Does Forgery Have to Do with the Digital Humanities? [PDF]
, 2019 McGrath’s chapter on the so-called Gospel of Jesus’ Wife sets aside as settled the question of the papyrus’ authenticity, and explores instead what we can learn about the Digital Humanities and scholarly interaction in a digital era from the way the ...
McGrath, James F
core +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
СТРУКТУРНІ ТА СТИЛІСТИЧНІ ОСОБЛИВОСТІ ПАМ’ЯТОК НАУКОВО-ПРАКТИЧНОГО ЖАНРУ XVIII СТ. (Structural and stylistic peculiarities of the memorial of scientific-practical Genre XVIII century.) [PDF]
, 2014 Порівняльний типологічний аналіз рукописів календарів XVIІІ ст. дозволив дослідити структуру, виділитий охарактеризувати специфічні стилістичні особливості пам’яток науково-практичного жанру.
Файчук, Т. (T. Faichuk)
core
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source