Simultaneous mapping of interactions between S&T knowledge bases: The case of space communications [PDF]
This paper examines the knowledge structure of the field of space communications using bibliometric mapping techniques based on textual analysis. A new approach with the aiming of visualizing simultaneously the configuration of its scientific and ...
emmanuel HASSAN
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Review of flipped learning in engineering education: Scientific mapping and research horizon. [PDF]
Educ Inf Technol (Dordr), 2022 Al Mamun MA +3 more
europepmc +1 more source
Tourism and Personality: Mapping Scientific Production
Applied TourismRecentemente, relevantes pesquisas foram feitas sobre a temática de personalidade nos estudos de Turismo, mas com abordagens específicas. A última revisão sobre o panorama geral data de 2010, abrangendo artigos de 1967 a 2009, abordando relações de trabalho, aspectos biológicos, psicológicos, socioculturais, cognitivos, de ajustamento e personalidade ...
Thais Bandinelli Vargas Lopes de Oliveira +2 more
openaire +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Future exploration of Venus (post-Pioneer Venus 1978) [PDF]
A comprehensive study was performed to determine the major scientific unknowns about the planet Venus to be expected in the post-Pioneer Venus 1978 time frame. Based on those results the desirability of future orbiters, atmospheric entry probes, balloons,
Colin, L. +6 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A Theoretical Framework on the Determinants of Food Purchasing Behavior of the Elderly: A Bibliometric Review with Scientific Mapping in Web of Science. [PDF]
Foods, 2021 Alhammadi K +2 more
europepmc +1 more source