Results 61 to 70 of about 2,220,924 (260)

Integrating artificial intelligence in unmanned vehicles: navigating uncertainties, risks, and the path forward for the fourth industrial revolution

Humanities & Social Sciences Communications
Artificial intelligence (AI) has been a field of research for nearly 80 years. Relevant technologies and products have widely been used in our daily lives, scientific research, and military fields.
Md Altab Hossin, Songtao Yin, Ruibo Dan, Lie Chen   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A Scientific Method for Startups

Journal of Management
Recent scholarship has sought to develop a “scientific method” for startups. In this paper we contrast two approaches: lean startup and the theory-based view of startups. The lean startup movement has served an important function in calling for a normative and scientific approach to startups and venture creation.
Felin, T., Gambardella, A., Novelli, E., Zenger, T.   +3 more
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Scientific integrity in research methods [PDF]

Frontiers in Psychology, 2015
Recent cases of research misconduct have prompted psychologists to suggest that there is too much vulnerability in the research process (e.g., Simmons et al., 2011; Pashler and Harris, 2012). Regardless of whether this is the case, ensuring the integrity of a discipline requires a clear understanding of what conventions and norms define the research ...
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The methodology of natural sciences in antiquity and the second book of Galen’s De placitis Hippocratis et Platonis [PDF]

SCHOLE, 2015
In this article, based on the second book of Galen’s De placitis Hippocratis et Platonis, we analyze scientific method of the famous anatomist and philosopher.
Koptseva, Natalia, Reznikova, Ksenia, Dobryaeva, Irina   +2 more
doaj  

Approximate Inference and Scientific Method

Information and Computation, 1994
AbstractA new identification criterion, motivated by notions of successively improving approximations in the philosophy of science, is defined. It shown that the class of recursive functions is identifiable under this criterion. This result is extended to apply to somewhat more realistic types of data than usual.
Mark A. Fulk, Sanjay Jain 0001
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source