Results 81 to 90 of about 2,220,924 (260)
Artificial intelligence, explainability, and the scientific method: A proof-of-concept study on novel retinal biomarker discovery. [PDF]
PNAS Nexus, 2023 Delavari P +4 more
europepmc +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
The Scientific Method as a Scaffold to Enhance Communication Skills in Chemistry. [PDF]
J Chem Educ, 2022 Montgomery TD +12 more
europepmc +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Early research on anther‐smut disease: A fuller view of science?
Ecology and EvolutionThe anther‐smut host–pathogen system has provided extensive insights into the evolutionary ecology of disease resistance, transmission modes, host shifts, pathogen specialization, and disease evolution in metapopulations.
Janis Antonovics, Helen M. Alexander
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Lost in the woods: Finding our way back to the scientific method in systematic review. [PDF]
Glob Epidemiol, 2022 Lynch HN +3 more
europepmc +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
ON THE TRANSDISCIPLINARY NATURE OF THE EPISTEMOLOGY OF DISCOVERY
Zygon, 1991 . Despite the by now historical tendency to demarcate scientific epistemology sharply from virtually all others, especially theological “epistemology,” it has recently been recognized that both enterprises share a great deal in common, at least as far ...
doaj +2 more sources
"'The scientific method' doesn't leave you". [PDF]
Signif (Oxf), 2021 Harkness T.
europepmc +1 more source