Results 91 to 100 of about 2,220,924 (260)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

SCIENCE, SPIRITUALITY, AND AYAHUASCA: THE PROBLEM OF CONSCIOUSNESS AND SPIRITUAL ONTOLOGIES IN THE ACADEMY

open access: yesZygon, 2017
Ayahuasca is a psychoactive brew from Amazonas, popularized in the last decades in part through transnational religious networks, but also due to interest in exploring spirituality through altered states of consciousness among academic schools and ...
doaj   +2 more sources

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

MAINTAINING RESPECTABILITY: RESPONSE TO NICHOLAOS JONES

open access: yesZygon, 2008
Nicholaos Jones argues that theology is not a respectable discipline because of its inability to meet the standards of contemporary science. Although Jones makes a bold claim, I suggest that he has not made his case by focusing on the question of ...
doaj   +2 more sources

How can we achieve health equity? Revisit the premise informing the scientific method. [PDF]

open access: yesHealth Expect, 2022
Fortuna KL   +5 more
europepmc   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

LEVELS OF ANALYSIS IN PHILOSOPHY, RELIGION, AND SCIENCE

open access: yesZygon, 2015
This article introduces a model of levels of analysis applied to statements found in philosophical, scientific, and religious discourses in order to facilitate a more accurate description of the relation between science and religion.
doaj   +2 more sources

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