Results 101 to 110 of about 18,383,772 (292)
Novel Confirmation and the Underdetermination of Scientific Theory Building [PDF]
, 2013 The extra value of novel confirmation over accommodation is explained based on an analysis of the underdetermination of scientific theory building.
Dawid, Richard
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
ON THE TRANSDISCIPLINARY NATURE OF THE EPISTEMOLOGY OF DISCOVERY
Zygon, 1991 . Despite the by now historical tendency to demarcate scientific epistemology sharply from virtually all others, especially theological “epistemology,” it has recently been recognized that both enterprises share a great deal in common, at least as far ...
doaj +2 more sources
Lost in the woods: Finding our way back to the scientific method in systematic review. [PDF]
Glob Epidemiol, 2022 Lynch HN +3 more
europepmc +1 more source
The clinical method and the scientific method [PDF]
, 2010 This paper is the chapter dedicated to the scientific method and the clinical method in the authors’ Handbook “Teaching of Clinics”. Philosophycal principles of the scientific method and its stages are presented as well as the clinical method as a ...
José A Fernández Sacasas +1 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
"'The scientific method' doesn't leave you". [PDF]
Signif (Oxf), 2021 Harkness T.
europepmc +1 more source
Book of Berkshire : papers by its Historical and Scientific Society.
, 1889 Mode of access ...
Berkshire Historical and Scientific Society.
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Why the Ultimate Argument for Scientific Realism Ultimately Fails [PDF]
, 2011 In this paper, I argue that the ultimate argument for Scientific Realism, also known as the No-Miracles Argument (NMA), ultimately fails as an abductive defence of Epistemic Scientific Realism (ESR), where (ESR) is the thesis that successful theories of ...
Mizrahi, Moti
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source