Results 101 to 110 of about 20,029,027 (295)

Book of Berkshire : papers by its Historical and Scientific Society.

, 1889
Mode of access ...
Berkshire Historical and Scientific Society.
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IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

La linguistica ante el reto de la aplicacion clinica. Linguistics: the challenge of clinical application. Proceedings of the internatinal conference of clinical linguistics. Victoria marrero, Idaira Pineda (eds), Universidad Nacional de Education a Distancia, Madrid. Scientific commetteee: Elisabetta Fava, Università di Ferrara

, 2009
Elisabetta fava was asked to be part of the Scientific committee of the International conference of clinical linguistics, Universidad Nacional de Education a Distancia, Madrid.
Scientific committee, FAVA, Elisabetta
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Biological Traits of Vertically Seed-Transmitted Bacillus mojavensis in Triticum aestivum L.

Microbiology Research
Seed-borne endophytic bacteria can influence host responses to biotic and abiotic stress conditions. Their presence in seeds is related to their ability to colonize plant tissues and to pass from parent plants to offspring. In this study, we investigated
Roderic Gilles Claret Diabankana, Daniel Mawuena Afordoanyi, Maria Nikolaevna Filimonova, Shamil Zavdatovich Validov, Radik Ilyasovich Safin   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Genomic Insights of Wheat Root-Associated Lysinibacillus fusiformis Reveal Its Related Functional Traits for Bioremediation of Soil Contaminated with Petroleum Products

Microorganisms
The negative ecological impact of industrialization, which involves the use of petroleum products and dyes in the environment, has prompted research into effective, sustainable, and economically beneficial green technologies.
Roderic Gilles Claret Diabankana, Akerke Altaikyzy Zhamalbekova, Aigerim Erbolkyzy Shakirova, Valeriia Igorevna Vasiuk, Maria Nikolaevna Filimonova, Shamil Zavdatovich Validov, Radik Ilyasovich Safin, Daniel Mawuena Afordanyi   +7 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Taking Policy for Granted in the Context of Scientific Innovation

, 2019
The purpose of this qualitative inquiry is to attempt to elucidate the policy attitude as it appears within the context of scientific innovation. A phenomenological anthropological approach to qualitative inquiry was utilized in order to explicate the ...
Englander, Magnus, Torbjörn Friberg, Friberg, Torbjörn,, Magnus Englander, Englander, Magnus,, Friberg, Torbjörn   +5 more
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