Results 121 to 130 of about 20,029,027 (295)
Scientific approaches to ancient wine : developments, challenges, and future perspectives
This introductory chapter outlines the remit and purpose of this book as one designed to survey current methods and approaches, especially those building new trajectories in the study of ancient viticulture and viniculture.
Van Limbergen, DimitrieditorUGent0001209757708020008022079733090572890000-0002-7554-651327A044EA-F0EE-11E1-A9DE-61C894A0A6B4 +3 more
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Pandemics and the development of scientific methods in the history of epidemiology. [PDF]
Colomb Med (Cali), 2020 Morabia A.
europepmc +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Semantic type checking in scientific workflows
, 2009 Scientists are increasingly utilizing Grids to manage large data sets and execute scientific experiments on distributed resources [1]. Scientific workflows are used as means for modelling and enacting scientific experiments [2].
Derouiche, Kheiredine
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Scientific knowledge and scientific uncertainty in bushfire and flood risk mitigation: literature review [PDF]
, 2015 EXECUTIVE SUMMARY The Scientific Diversity, Scientific Uncertainty and Risk Mitigation Policy and Planning (RMPP) project aims to investigate the diversity and uncertainty of bushfire and flood science, and its contribution to risk mitigation policy ...
Timothy Neale, Neale, Timothy (R17932)
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
COVID-19 pandemic and personal protective equipment shortage: protective efficacy comparing masks and scientific methods for respirator reuse. [PDF]
Gastrointest Endosc, 2020 Boškoski I +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
DEVELOPING KEY COMPETENCIES THROUGH SCIENTIFIC LITERACY IN 4TH GRADE [PDF]
The article provides an overview of existing methods and approaches for developing key competencies in fourth-grade students through scientific literacy.
Irina Mishkova-Yotova +2 more
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