Results 71 to 80 of about 20,029,027 (295)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Public Relations as Scientific Branch of Information and Communication Sciences
Medijske Studije, 2012 Given that the field of information and communication sciences is a young field in the social sciences, it is important to consider how technology impacts the development of this field.
Hrvoje Jakopović
doaj
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
El “Cinturón estepario” de culturas ganaderas en Eurasia durante la Primera Edad del Metal
Trabajos de Prehistoria, 2008 Las culturas ganaderas del “cinturón estepario” de Eurasia cubrieron aproximadamente 7-8 millones de km2, entre el bajo Danubio al oeste y Manchuria al este (una distancia de más de 8000 km).
Evgeny Chernykh
doaj +1 more source
A Scientific Method for Startups
Journal of ManagementRecent scholarship has sought to develop a “scientific method” for startups. In this paper we contrast two approaches: lean startup and the theory-based view of startups. The lean startup movement has served an important function in calling for a normative and scientific approach to startups and venture creation.
Felin, T. +3 more
openaire +3 more sources
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
FermentationPseudomonas putida PCL1760 is a well-studied bacterium that can be used for a wide range of biotechnological applications. In our study we investigated the effect of deletion of the genes involved in alginate accumulation (algA), flagellar export (flhA),
Mikhail Frolov +5 more
doaj +1 more source
EFFICIENCY OF MEDICAL REHABILITATION IN ARTERIAL HYPERTENSION AS A PART OF THE SPA RESORT TREATMENT
Евразийский Кардиологический Журнал, 2018 Medical rehabilitation (MR) has become one of the important tasks of treatment in patients with arterial hypertension (AH). The aim - assessment of the effectiveness of spa resort MR in patients with AH under spa resort treatment (SRT) in view of the ...
A. S. Ivashchenko +3 more
doaj +1 more source