Results 41 to 50 of about 9,610,808 (253)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Proposals for evaluating the regularity of a scientist'sresearch output [PDF]

, 2011
Evaluating the career of individual scientists according to their scientific output is a common bibliometric problem. Two aspects are classically taken into account: overall productivity and overall diffusion/impact, which can be measured by a plethora ...
Franceschini, Fiorenzo, Fiorenzo Franceschini, Maisano, Domenico Augusto Francesco, Domenico Maisano   +3 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Scientific output: labor or capital intensive? An analysis for selected countries [PDF]

, 2016
Scientific research contributes to sustainable economic growth environments. Hence, policy-makers should understand how the different inputs—namely labor and capital—are related to a country’s scientific output.
Erfanian, Elham, Ferreira Neto, Amir Borges, Elham Erfanian, Amir B. Ferreira Neto   +3 more
core   +1 more source

The First Four Years of Current Research in MRI

Current Research in MRI
Objective: To evaluate the early publication and editorial profile of Current Research in MRI (CRMRI) through a descriptive publication analysis covering the journal’s first four years. Methods: All articles published in CRMRI between 2022 and 2025 were
Ali Salbas, Atilla Hikmet Çilengir
doaj   +1 more source

A Scientometric Assessment of the Medical Universities Performance: Two Decades Analysis from 1998 to 2018 [PDF]

Journal of Health Management & Informatics, 2019
Introduction: Given the key role of universities and higher education institutes in thesocial and economic development of countries, it is necessary to evaluate their performance regularly with appropriate methods and measures. Since research and science
Mohammad Reza Zare Banadkouki
doaj  

Mapping the Knowledge Structure of Science and Technology PolicyMaking Process Studies: A Scientometric Analysis of Trends, Influential Authors, and Thematic Structures in the Scopus [PDF]

پژوهشنامه علم سنجی
Purpose: This research aims to investigate the evolution and dynamics of scientific outputs related to science and technology policymaking processes by analyzing publications indexed in Scopus.
Fereshteh Tabarsa, Mohammad Hassanzadeh, Atefeh Sharif, Ali Shayan, Faeze Eskandari   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source