Results 41 to 50 of about 1,358,414 (241)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The high-voltage lateral p-channel MOS-transistor making optimization

Технологія та конструювання в електронній апаратурі, 2006
Simulation of semiconductor structures provides an opportunity to reduce manufacturing costs and optimize the parameters of integrated circuit elements and devices.
N. I. Leonov, A. M. Lemeshevskaya, N. L. Dudar, S. N. Getzman   +3 more
doaj  

A plant-biotechnology approach for producing highly potent anti-HIV antibodies for antiretroviral therapy consideration

Journal of Genetic Engineering and Biotechnology, 2021
Despite a reduction in global HIV prevalence the development of a pipeline of new therapeutics or pre-exposure prophylaxis to control the HIV/AIDS epidemic are of high priority.
Advaita Acarya Singh, Priyen Pillay, Lusisizwe Kwezi, Tsepo Lebiletsa Tsekoa   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Reliability and Quality of Complex Systems

Надежность и качество сложных систем
Background. Prolonged operation of gas pipeline shut-off valves leads to gradual wear of the sealing elements of ball valves and, as a result, to their leakiness.
D.S. Boyarkin, V.D. Yezhizhanskiy, D.A. Golushko, I.R. Abuzyarov, A.V. Lysenko   +4 more
doaj   +2 more sources

Features of designing internal power supply circuits for micropower ICs based on injection logic elements

Технологія та конструювання в електронній апаратурі, 2008
Control of the ohmic resistance of “hidden layers” of the n+-type using a mathematical model based on an elementary cell of equivalent lumped conductance with partitioning along two coordinates makes it possible to significantly reduce the variation of ...
A. I. Belous, V. A. Emel’yanov, V. S. Syakersky, A. V. Silin   +3 more
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Curcuit-design solutions for producing devices of feed water flow rate control systems

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2016
Creation of a low-noise water flow control systems apparatus is the main objective of the research. The technique of carrying out the tests is based on the principles of acoustics, flow mechanics and the control theory. The main schemes of regulating the
E. G. Berestovitsky, Yu. A. Gladilin, N. V. Pyalov, M. V. Solovyev, M. A. Ermilov   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

PROTOCOL OF REGISTRATION OF MAINTENANCE OF PIPELINE FITTINGS

Надежность и качество сложных систем
Background. The method of registration of maintenance and repair of pipeline fittings using RFID technology (Radio Frequency Identification, radio frequency identification) is considered.
D.S. Boyarkin, E.A. Aseev, D.A. Golushko, I.R. Abuzyarov, A.V. Lysenko   +4 more
doaj   +1 more source