Results 61 to 70 of about 1,358,414 (241)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Validation of the method for determination of prekallikrein activator in Human Albumin

Биопрепараты: Профилактика, диагностика, лечение, 2018
Prekallikrein activator (PKA) is regarded as one of the most important factors determining the safety of blood products such as albumin and intravenous immunoglobulin.
M. V. Tomilin, E. V. Filatova, M. M. Kuznetsova, V. V. Sudakova, N. V. Zubkova   +4 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Procedure of estimating characteristics of angular velocity meter using the Kalman filter and Allan variance

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2016
A procedure of assessing the main characteristics of angular velocity inertial meters of middle and low accuracy classes, including measuring channel noise terms is proposed.
D. A. Kutovoy, O. I. Maslova, S. Y. Perepelkina, Y. S. Tiunov, A. A. Fedotov   +4 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Measuring. Monitoring. Management. Control

Измерение, мониторинг, управление, контроль
Background. The use of natural gas as a fuel is becoming increasingly popular, as gas is more environmentally friendly and cheaper than gasoline. To refuel equipment with gas fuel, an automotive gas-filling compressor station is used, where compression ...
V.D. Yezhizhanskiy, D.S. Boyarkin, D.A. Golushko, I.R. Abuzyarov, A.V. Lysenko   +4 more
doaj   +1 more source

Dynamics of feed water flow rate control system with low- noise regulator

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2017
We present the results of modeling a feed water control system. The system contains two regulatory devices the feed valve to control the flow rate, with electrohydraulic control, and the throttle valve to maintain constant pressure differential on the ...
E. G. Berestovitskiy, P. I. Kizilov, A. N. Kruchkov, N. V. Pialov   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Reference Intervals of Mass Coefficients and Absolute Weights of Mini Pigs’ Organs

Ветеринарная патология
Introduction. Measurement of weights and calculation of mass coefficients of the laboratory animals’ internal organs are the integral stages of toxicological research. However, the absence of the correct intra-laboratory reference intervals corresponding
E. V. Simonova, A. I. Savvateikina, K. T. Sultanova, M. N. Makarova, E. V. Mazukina   +4 more
doaj   +1 more source