Results 61 to 70 of about 12,733,834 (284)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Characterizing scientific production and consumption in physics [PDF]

, 2013
We analyze the entire publication database of the American Physical Society generating longitudinal (50 years) citation networks geolocalized at the level of single urban areas.
Perra, Nicola, Goncalves, Bruno, Ciulla, Fabio, Zhang, Qian, Vespignani, Alessandro   +4 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Instrumentation support for modeling the operation of complex radio-electronic devices

Технологія та конструювання в електронній апаратурі, 2002
The possibility of effective modeling of complex devices for various branches of the radio-electronic industry using foreign and domestic (Minsk Research Instruments-Production Institute) equipment is demonstrated.
V. A. Yemelyanov, V. N. Ponomar, A. A. Soloninko, H. H. Chygyr, B. N. Lisenkov   +4 more
doaj  

RESULTS OF A MULTICENTER CLINICAL STUDY OF A NEW COMBINATION VACCINE DTaP-HepB+Hib PRODUCTION OF THE CPA «MICROGEN» FOR IMMUNIZATION OF CHILDREN 6 MONTHS

Журнал микробиологии, эпидемиологии и иммунобиологии, 2018
Aim. The aim of the study is evaluate of reactogenicity, safety and immunogenicity of the native combined vaccine DTaP-HepB+Hib. Materials and methods. Assessment of reactogenicity, safety and immunogenicity of the drug is investigated in a multicenter ...
I. V. Feldblyum, V. V. Romanenko, A. M. Nikolaeva, K. A. Subbotina, O. Yu. Sosnina, O. A. Perminova, O. V. Belyakova, T. V. Danilina, A. E. Ershov, D. M. Trofimov, E. A. Bykova, S. V. Martirosyan, A. V. Ankudinova   +12 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Scientific Method

, 2008
Many think the scientific method is a complicated formula used only by those with a degree in chemistry. In reality, the scientific method is a system of reasoning which can be used to solve almost any type of problem.

core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

On scaling of scientific knowledge production in U.S. metropolitan areas

, 2014
Data underlying the findings described in the study "On scaling of scientific knowledge production in U.S. metropolitan areas" by Önder Nomaler (School of Innovation Sciences, Eindhoven University of Technology, The Netherlands), Koen Frenken and Gaston ...
Frenken, Prof. Dr. K. (Utrecht University) DAI=info:eu-repo/dai/nl/207145253, Nomaler, Z.O. (Eindhoven University of Technology), Heimeriks, Dr. G.J. (Utrecht University) DAI=info:eu-repo/dai/nl/291061664   +2 more
core   +1 more source