Results 151 to 160 of about 662,628 (289)

Scientific integrity at Science Advances: Essential pillar supporting scientific progress. [PDF]

Sci Adv, 2021
Yeagle P.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Misunderstanding Understanding Scientific Progress

In my book Understanding Scientific Progress, I argue that fundamental philosophical problems about scientific progress, above all the problem of induction, cannot be solved granted standard empiricism (SE), a doctrine which most scientists and ...
Maxwell, Nicholas
core  

COVID-19: Main findings after a year and half of unease and the proper scientific progress (Review). [PDF]

Exp Ther Med, 2022
Leretter MT, Vulcanescu DD, Horhat FG, Matichescu A, Rivis M, Rusu LC, Roi A, Racea R, Badea I, Dehelean CA, Mocanu A, Horhat DI.   +11 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Reevaluating scientific progress as a problem resolution

Azafea: Revista de Filosofía, 2015
“Problem-solving” as a criterion of scientific progress defended by Thomas S. Kuhn and Larry Laudan, respectively, has been criticized by several authors.
Damián ISLAS
doaj  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Scientific Progress and Modern Cosmology [PDF]

The paper examines the nature of scientific progress through the lens of the history of modern cosmology (i.e. from Einstein’s 1917 static universe to the present-day Standard (ΛCDM) model of cosmology).
Dürr, Patrick, Dellsén, Finnur
core   +2 more sources

Research overview-2025: integrating scientific progress to accelerate global tuberculosis elimination. [PDF]

Front Tuberc
Moonan PK, Holtz TH.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source