Results 131 to 140 of about 2,685,069 (299)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Consciousness Science Underdetermined: A short history of endless debates [PDF]
, 2019 Consciousness scientists have not reached consensus on two of the most central questions in their field: first, on whether consciousness overflows reportability; second, on the physical basis of consciousness.
Michel, Matthias
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Chromatographic-Based Platforms as New Avenues for Scientific Progress and Sustainability. [PDF]
Molecules, 2022 Câmara JS +4 more
europepmc +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Ekonomika Nauki, 2015 The article presents an economic analysis of expenses for patenting and by using leading technical universities as an example, it demonstrates the lack of economic practicability of patent activity in a situation, when only 6–12% of patents for ...
V. G. Zinov, O. I. Kupriyanova
doaj
Publications of the Jet Propulsion Laboratory, 1981 [PDF]
Over 500 externally distributed technical reports released during 1981 that resulted from scientific and engineering work performed, or managed by Jet Propulsion Laboratory are listed by primary author.
core +1 more source
The scientific progress and prospects of artificial intelligence in digestive endoscopy: A comprehensive bibliometric analysis. [PDF]
Medicine (Baltimore), 2022 Gan PL +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
The Enlightenment, Popper and Einstein [PDF]
, 2007 A basic idea of the 18th century French Enlightenment was to learn from scientific progress how to achieve social progress towards an enlightened world. Unfortunately, the philosophes developed this profoundly important idea in a seriously defective form,
Maxwell, N
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