Results 121 to 130 of about 2,685,069 (299)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Kuhn, Conspiracy Theories, and Scientific Progress

Zygon
This article offers an appreciative but critical response to Donovan Schaefer’s book Wild Experiment, focusing on the connection between emotion and reason, particularly in the context of conspiracy theories and scientific inquiry.
Josh A. Reeves
doaj   +2 more sources

Microglia and cognitive impairment in schizophrenia: translating scientific progress into novel therapeutic interventions. [PDF]

Schizophrenia (Heidelb), 2023
Zhuo C, Tian H, Song X, Jiang D, Chen G, Cai Z, Ping J, Cheng L, Zhou C, Chen C.   +9 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Critica asupra modelarii economice si progresul stiintific

Perspective Politice, 2015
In this paper I intend to bring some academic focus on the main criticisms of the methodology used by public choice theory. The purpose of this is aimed at discovering if the current methodological trend may be considered desirable from the point of view
Horia Andrei POPESCU
doaj  

Accuracy-First Epistemology and Scientific Progress

Ergo, An Open Access Journal of Philosophy
The accuracy-first program attempts to ground epistemology in the norm that one’s beliefs should be as accurate as possible, where accuracy is measured using a scoring rule.
Branden Fitelson, Don Fallis, Peter Lewis   +2 more
doaj   +2 more sources

NNOVATIONS IN AGRICULTURE AND THE INDICATORS OF THE LEVEL AND EFFECTIVENESS OF THEIR APPLICATION IN PHYTOTECHNICAL BRANCH [PDF]

Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2013
The integration of scientific and technical progress in agriculture development strategies contribute to stimulating sustainable economic growth, based on a scientific basis, which takes into consideration the objectives of mankind: conservation of ...
Diana MEMET
doaj  

Understanding and scientific progress: lessons from epistemology. [PDF]

Synthese, 2022
Emmerson N.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

European Culture in a State of Crisis: Joseph Ratzinger’s Diagnosis / Kultura europejska w stanie kryzysu: diagnoza Josepha Ratzingera [PDF]

Studia Gilsoniana, 2017
European culture, according to Joseph Ratzinger, is seriously undermined by a modernist (rationalistic) and postmodernist (irrationalistic) way of thinking which deeply penetrates it.
Krystyna Rojek
doaj