Results 111 to 120 of about 662,628 (289)

Accuracy-First Epistemology and Scientific Progress

Ergo, An Open Access Journal of Philosophy
The accuracy-first program attempts to ground epistemology in the norm that one’s beliefs should be as accurate as possible, where accuracy is measured using a scoring rule.
Branden Fitelson, Don Fallis, Peter Lewis   +2 more
doaj   +2 more sources

NNOVATIONS IN AGRICULTURE AND THE INDICATORS OF THE LEVEL AND EFFECTIVENESS OF THEIR APPLICATION IN PHYTOTECHNICAL BRANCH [PDF]

Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2013
The integration of scientific and technical progress in agriculture development strategies contribute to stimulating sustainable economic growth, based on a scientific basis, which takes into consideration the objectives of mankind: conservation of ...
Diana MEMET
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

European Culture in a State of Crisis: Joseph Ratzinger’s Diagnosis / Kultura europejska w stanie kryzysu: diagnoza Josepha Ratzingera [PDF]

Studia Gilsoniana, 2017
European culture, according to Joseph Ratzinger, is seriously undermined by a modernist (rationalistic) and postmodernist (irrationalistic) way of thinking which deeply penetrates it.
Krystyna Rojek
doaj  

Microglia and cognitive impairment in schizophrenia: translating scientific progress into novel therapeutic interventions. [PDF]

Schizophrenia (Heidelb), 2023
Zhuo C, Tian H, Song X, Jiang D, Chen G, Cai Z, Ping J, Cheng L, Zhou C, Chen C.   +9 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Scientific Research and Growth Volatility

This article uncovers a strong link between scientific and engineering publications on the one hand, and growth volatility on the other: growth volatility is significantly lowered by a country’s ability to publish more scientific and engineering journal ...
Sam Tang
core  

Understanding and scientific progress: lessons from epistemology. [PDF]

Synthese, 2022
Emmerson N.
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source