Results 111 to 120 of about 2,685,069 (299)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The Child is Father of the Man: Foresee the Success at the Early Stage

, 2015
Understanding the dynamic mechanisms that drive the high-impact scientific work (e.g., research papers, patents) is a long-debated research topic and has many important implications, ranging from personal career development and recruitment search, to the
Golub G. H., Jalali A., Saunders C., Sun Y.   +3 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Considerations on the Fundamental Relationship between Clinical Psychology and Epistemology

Mediterranean Journal of Clinical Psychology
Clinical psychology is a scientific discipline whose origins are complex and multidisciplinary (Benjamin, 2005; Brems et al., 1991; Merlo, 2023; Watson, 1953). As this field continues to evolve, multidisciplinary work is becoming of increasing importance.
Emanuele Maria Merlo
doaj   +1 more source

Particle acceleration, transport and turbulence in cosmic and heliospheric physics [PDF]

In this progress report, the long term goals, recent scientific progress, and organizational activities are described. The scientific focus of this annual report is in three areas: first, the physics of particle acceleration and transport, including ...
Matthaeus, W.
core   +1 more source

Imagination: A Sine Qua Non of Science [PDF]

, 2017
What role does the imagination play in scientific progress? After examining several studies in cognitive science, I argue that one thing the imagination does is help to increase scientific understanding, which is itself indispensable for scientific ...
Stuart, Michael T.
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The boundaries of Soviet science [PDF]

Soviet scientific and technological progress in 1966, and utilization of science for improved national ...

core   +1 more source

Dark Matter and MOOCs [PDF]

, 2013
To teach the topic of Dark Matter in Galaxies to undergraduate and PhD students is not easy, one reason being that the scientific community has not converged yet to a generally shared knowledge. We argue that the teaching of this topic and its subsequent
Antolini, Claudia, Salucci, Paolo
core  

From "Not Wrong" to (Maybe) Right

, 2004
This is a short, light spirited account of how some possibly important science actually happened. It very much conflicts with Popper's contention that the key to scientific progress is falsification.Comment: This is, in essence, a solicited "Turning ...
Wilczek, Frank
core   +2 more sources