Results 101 to 110 of about 662,628 (289)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Kuhn, Conspiracy Theories, and Scientific Progress

Zygon
This article offers an appreciative but critical response to Donovan Schaefer’s book Wild Experiment, focusing on the connection between emotion and reason, particularly in the context of conspiracy theories and scientific inquiry.
Josh A. Reeves
doaj   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The Scientific Practice of Assessing Progress [PDF]

, 2011
In a recent debate about the nature of scientific progress, Alexander Bird and Darrell Rowbottom have argued for two competing accounts of progress. According to Bird, scientific progress consists in the accumulation of scientific knowledge.
Mizrahi, Moti
core  

Progress in Physics: 10 Years in Print

, 2015
In January, 2015, we celebrate first 10 years of our journal Progress in Physics. This is a good time to remember what events led to the idea of the journal, and how the journal was founded.
Progress in Physics
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Considerations on the Fundamental Relationship between Clinical Psychology and Epistemology

Mediterranean Journal of Clinical Psychology
Clinical psychology is a scientific discipline whose origins are complex and multidisciplinary (Benjamin, 2005; Brems et al., 1991; Merlo, 2023; Watson, 1953). As this field continues to evolve, multidisciplinary work is becoming of increasing importance.
Emanuele Maria Merlo
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

On Scientific Progress [PDF]

A central question in philosophy of science and epistemology of science concerns the characterization of the progress of science. Many philosophers of science and epistemologists have developed accounts of scientific progress, laying down desiderata for ...
Bakshi, Kabir S.
core  

Critica asupra modelarii economice si progresul stiintific

Perspective Politice, 2015
In this paper I intend to bring some academic focus on the main criticisms of the methodology used by public choice theory. The purpose of this is aimed at discovering if the current methodological trend may be considered desirable from the point of view
Horia Andrei POPESCU
doaj