Results 91 to 100 of about 586,771 (255)

Microglia and cognitive impairment in schizophrenia: translating scientific progress into novel therapeutic interventions. [PDF]

Schizophrenia (Heidelb), 2023
Zhuo C, Tian H, Song X, Jiang D, Chen G, Cai Z, Ping J, Cheng L, Zhou C, Chen C.   +9 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Critica asupra modelarii economice si progresul stiintific

Perspective Politice, 2015
In this paper I intend to bring some academic focus on the main criticisms of the methodology used by public choice theory. The purpose of this is aimed at discovering if the current methodological trend may be considered desirable from the point of view
Horia Andrei POPESCU
doaj  

Accuracy-First Epistemology and Scientific Progress

Ergo, An Open Access Journal of Philosophy
The accuracy-first program attempts to ground epistemology in the norm that one’s beliefs should be as accurate as possible, where accuracy is measured using a scoring rule.
Branden Fitelson, Don Fallis, Peter Lewis   +2 more
doaj   +2 more sources

NNOVATIONS IN AGRICULTURE AND THE INDICATORS OF THE LEVEL AND EFFECTIVENESS OF THEIR APPLICATION IN PHYTOTECHNICAL BRANCH [PDF]

Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2013
The integration of scientific and technical progress in agriculture development strategies contribute to stimulating sustainable economic growth, based on a scientific basis, which takes into consideration the objectives of mankind: conservation of ...
Diana MEMET
doaj  

Understanding and scientific progress: lessons from epistemology. [PDF]

Synthese, 2022
Emmerson N.
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

European Culture in a State of Crisis: Joseph Ratzinger’s Diagnosis / Kultura europejska w stanie kryzysu: diagnoza Josepha Ratzingera [PDF]

Studia Gilsoniana, 2017
European culture, according to Joseph Ratzinger, is seriously undermined by a modernist (rationalistic) and postmodernist (irrationalistic) way of thinking which deeply penetrates it.
Krystyna Rojek
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Chromatographic-Based Platforms as New Avenues for Scientific Progress and Sustainability. [PDF]

Molecules, 2022
Câmara JS, Martins C, Pereira JAM, Perestrelo R, Rocha SM.   +4 more
europepmc   +1 more source