Results 91 to 100 of about 2,685,069 (299)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Metaphor as a Factor of Evolutionary Variability of Scientific Theories
АнтиномииThe article analyzes philosophical problems related to the study of the verbalization of new knowledge. Special attention is given to identifying the place and role of metaphor in the linguistic expression of this knowledge.
Alexander M. Zharov
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Zagadnienia Filozoficzne w Nauce, 2011 We analyse the position of David C. Stove who accuses Popper, Kuhn, Feyerabend and Lakatos of being irrationalists. We concentrate on the subject whether this accusation is correct as far as Popper is concerned.
Stanisław Hanuszewicz
doaj
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Felsefe Dünyası, 2015 XX. yüzyılın ikinci yarısından itibaren bilimsel ilerlemenin doğasınıanlamaya ve açıklamaya yönelik birtakım tezler ileri sürülmüşse de halenbu tezler tartışılmaktadır.
Ercan Salgar
doaj
SCIENTIFIC-TECHNOLOGICAL PROGRESS OF UZBEKISTAN: PROBLEMS AND PROSPECTS [PDF]
The article considers aspects concerning effective coordination of scientific-technological development in Uzbekistan. In the conditions of new economy, insufficient development and use of innovations in the domestic economy will contain the rate of ...
Azimov, Abror
core +1 more source
On the Multidimensionality of Scientific Rationality and Scientific Progress
Epistemology & Philosophy of Science, 2023 In the polemic with T.D. Sokolova’s article the issue is discussed addressing the question whether there is anything new that we can get from the methodology of interdisciplinarity and trans-disciplinarity for determination of scientific rationality and scientific progress.
openaire +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source