Results 71 to 80 of about 586,771 (255)

Metaphor as a Factor of Evolutionary Variability of Scientific Theories

Антиномии
The article analyzes philosophical problems related to the study of the verbalization of new knowledge. Special attention is given to identifying the place and role of metaphor in the linguistic expression of this knowledge.
Alexander M. Zharov
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ANÁLISIS DEL TIPO DE INTERACCIONES QUE OCURREN ENTRE INVESTIGADORES DURANTE LA PRESENTACIÓN DE TRABAJOS ACADÉMICOS

Acta Colombiana de Psicología, 2014
Although it is considered that scientific development and intellectual progress occur through the exchange of ideas brought about by the interaction among scientists, the type of interactions that take place among researchers when one of them presents ...
Padilla Vargas, María Antonia
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TECHNICAL SCIENTIFIC PROGRESS AND SOCIETY DEVELOPMENT [PDF]

Fiabilitate şi Durabilitate, 2020
This paper conducts a study on the role of science in technical and scientific progress and development of society, for a technological economy and in the evolution of modern technological society, information society (digitization, digital signal ...
Adina TĂTAR
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

O racjonalną krytykę racjonalizmu krytycznego - teoria postępu naukowego w ujęciu Popperowskiego racjonalizmu krytycznego

Zagadnienia Filozoficzne w Nauce, 2011
We analyse the position of David C. Stove who accuses Popper, Kuhn, Feyerabend and Lakatos of being irrationalists. We concentrate on the subject whether this accusation is correct as far as Popper is concerned.
Stanisław Hanuszewicz
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

BİLİMSEL İLERLEME NEDİR?

Felsefe Dünyası, 2015
XX. yüzyılın ikinci yarısından itibaren bilimsel ilerlemenin doğasınıanlamaya ve açıklamaya yönelik birtakım tezler ileri sürülmüşse de halenbu tezler tartışılmaktadır.
Ercan Salgar
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source