Results 61 to 70 of about 662,628 (289)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
The progress of demography as a scientific discipline [PDF]
Demography, 1979 The discipline of demography deals with the size composition distribution and characteristics of populations and how the factors interact and change. Demography also includes the internal and external dynamics of population. Data collection is hampered because censuses are infrequent so records of births marriages and deaths are crucial for interim ...
openaire +2 more sources
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Justifying Scientific Progress [PDF]
I defend a novel account of scientific progress centred around justification. Science progresses, on this account, where there is a change in justification. I consider three options for explicating this notion of change in justification.
Stegenga, Jacob
core +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
The Scientist, Qua Scientist, Is an Ethical Agent
FilozofiaI argue that the currently confused talk about “values in science” should be understood in terms of schemes of values. The new demarcation problem is then formulated as asking “Which scheme(s) of values should scientists adopt?” I defend the view that ...
Philip Kitcher
doaj +1 more source
Waging war and scientific progress [PDF]
Advances in Health Sciences Education, 2012 I am a fan of wars. I love to read anything, fiction or non-fiction, about the wars of the twentieth century, hot or cold. I love to watch spy movies. I’ve seen The Dambusters 29 times. However macabre this may seem, I am not alone, as the steady stream of books, movies and documentaries about war that emerge year after year attests.
openaire +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Scientific Progress: By-Whom or For-Whom? [PDF]
, 2022 When science makes cognitive progress, who or what is it that improves in the requisite way? According to a widespread and unchallenged assumption, it is the cognitive attitudes of scientists themselves, i.e.
Dellsén, Finnur
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source