Results 61 to 70 of about 2,685,069 (299)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
NEGACIONISMO CIENTíFICO: PRÁTICA ANTIGA E PERSISTENTE AO LONGO DA HISTÓRIA [PDF]
Química NovaSCIENTIFIC DENIALISM: AN ANCIENT AND PERSISTENT PRACTICE THROUGHOUT HISTORY. The search for scientific truth has long been the target of denialism, which obstructs progress and demands perseverance from those advocating new discoveries.
Luiz C. A. Barbosa +1 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
We Need to Recreate Natural Philosophy
Philosophies, 2018 Modern science began as natural philosophy, an admixture of philosophy and science. It was then killed off by Newton, as a result of his claim to have derived his law of gravitation from the phenomena by induction.
Nicholas Maxwell
doaj +1 more source
Progress toward a cosmic dust collection facility on space station [PDF]
, 1988 Scientific and programmatic progress toward the development of a cosmic dust collection facility (CDCF) for the proposed space station is documented. Topics addressed include: trajectory sensor concepts; trajectory accuracy and orbital evolution; CDCF ...
Carey, William C., Mackinnon, Ian D. R.
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Monitoring of Iranian pharmaceutical studies in the last decade: A scientometric study [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریزBackground. Scientometrics has a significant impact on research policies, allocation of research budgets, equipping research centers, and setting research priorities.
Sara Jalalzadeh +3 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Biographical narrative in the novel “Measuring the World” by Daniel Kehlmann
Journal of Modern Science, 2020 The article studies the problem of biographical narrative in the novel «Measuring the World» by Austrian writer Daniel Kelman. The purpose of the research is to consider genre features of the work, to determine its literary structure, the narrative ...
Ivan Megela, Kateryna Mehela
doaj +1 more source
The progress of demography as a scientific discipline [PDF]
Demography, 1979 The discipline of demography deals with the size composition distribution and characteristics of populations and how the factors interact and change. Demography also includes the internal and external dynamics of population. Data collection is hampered because censuses are infrequent so records of births marriages and deaths are crucial for interim ...
openaire +2 more sources