Results 51 to 60 of about 662,628 (289)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Optimistic realism about scientific progress [PDF]
, 2017 Scientific realists use the "no miracle argument" to show that the empirical and pragmatic success of science is an indicator of the ability of scientific theories to give true or truthlike representations of unobservable reality.
Niiniluoto, Ilkka
core +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
NEGACIONISMO CIENTíFICO: PRÁTICA ANTIGA E PERSISTENTE AO LONGO DA HISTÓRIA [PDF]
Química NovaSCIENTIFIC DENIALISM: AN ANCIENT AND PERSISTENT PRACTICE THROUGHOUT HISTORY. The search for scientific truth has long been the target of denialism, which obstructs progress and demands perseverance from those advocating new discoveries.
Luiz C. A. Barbosa +1 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
We Need to Recreate Natural Philosophy
Philosophies, 2018 Modern science began as natural philosophy, an admixture of philosophy and science. It was then killed off by Newton, as a result of his claim to have derived his law of gravitation from the phenomena by induction.
Nicholas Maxwell
doaj +1 more source
Biographical narrative in the novel “Measuring the World” by Daniel Kehlmann
Journal of Modern Science, 2020 The article studies the problem of biographical narrative in the novel «Measuring the World» by Austrian writer Daniel Kelman. The purpose of the research is to consider genre features of the work, to determine its literary structure, the narrative ...
Ivan Megela, Kateryna Mehela
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Institutions and Scientific Progress [PDF]
, 2020 Scientific progress has many facets and can be conceptualized in different ways, for example in terms of problem-solving, of truthlikeness or of growth of knowledge.
Mantzavinos, C.
core +1 more source
Monitoring of Iranian pharmaceutical studies in the last decade: A scientometric study [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریزBackground. Scientometrics has a significant impact on research policies, allocation of research budgets, equipping research centers, and setting research priorities.
Sara Jalalzadeh +3 more
doaj +1 more source