Results 51 to 60 of about 586,771 (255)
We Need to Recreate Natural Philosophy
Philosophies, 2018 Modern science began as natural philosophy, an admixture of philosophy and science. It was then killed off by Newton, as a result of his claim to have derived his law of gravitation from the phenomena by induction.
Nicholas Maxwell
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Waging war and scientific progress [PDF]
Advances in Health Sciences Education, 2012 I am a fan of wars. I love to read anything, fiction or non-fiction, about the wars of the twentieth century, hot or cold. I love to watch spy movies. I’ve seen The Dambusters 29 times. However macabre this may seem, I am not alone, as the steady stream of books, movies and documentaries about war that emerge year after year attests.
openaire +2 more sources
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Monitoring of Iranian pharmaceutical studies in the last decade: A scientometric study [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریزBackground. Scientometrics has a significant impact on research policies, allocation of research budgets, equipping research centers, and setting research priorities.
Sara Jalalzadeh +3 more
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FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The Scientist, Qua Scientist, Is an Ethical Agent
FilozofiaI argue that the currently confused talk about “values in science” should be understood in terms of schemes of values. The new demarcation problem is then formulated as asking “Which scheme(s) of values should scientists adopt?” I defend the view that ...
Philip Kitcher
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The progress of demography as a scientific discipline [PDF]
Demography, 1979 The discipline of demography deals with the size composition distribution and characteristics of populations and how the factors interact and change. Demography also includes the internal and external dynamics of population. Data collection is hampered because censuses are infrequent so records of births marriages and deaths are crucial for interim ...
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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