Results 51 to 60 of about 2,685,069 (299)
Resultados Experimentais, Problemas Conceituais e Progresso Científico
Dados: Revista de Ciências Sociais, 1997 If we affirm that scientific knowledge advances, we are implying there is some degree of continuity between given experimental results and given solutions to conceptual problems.
Freitas Renan Springer de
doaj
Natural History: the sense of wonder, creativity and progress in ecology
Scientia Marina, 2001 This essay addresses the question of blending natural history and ecological wisdom into the genuine creativity exemplified by Prof. Ramon Margalef. Many have observed that modern biology is a triumph of precision over accuracy, and that ecology has ...
Paul K. Dayton, Enric Sala
doaj +1 more source
Measuring progress in robotics: Benchmarking and the ‘measure-target confusion’ [PDF]
, 2019 While it is often said that robotics should aspire to reproducible and measurable results that allow benchmarking, I argue that a focus on benchmarking can be a hindrance for progress in robotics. The reason is what I call the ‘measure-target confusion’,
Müller, Vincent C.
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Technology Philosophical Assessment: Some Reasons for Optimism [PDF]
, 2012 The author presents a schematic outline of two approaches in contemporary philosophy of technology, the first of which is rather pessimistic, with technological progress seen as a rising force which subjugates humans and, to use Martin Heidegger’s words,
Waloszczyk, Konrad
core +1 more source
Immunogens and Antigen Processing: Report from a Global HIV Vaccine Enterprise Working Group [PDF]
, 2010 The Global HIV Vaccine Enterprise convened a meeting of a Working Group in July 2009 to discuss recent progress in rational design of the components of an HIV vaccine, such as inserts, vectors and adjuvants,and in understanding antigen processing and ...
John Mascola +3 more
core +3 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Attributing scientific and technological progress: The case of holography [PDF]
Holography, the three-dimensional imaging technology, was portrayed widely as a paradigm of progress during its decade of explosive expansion 1964–73, and during its subsequent consolidation for commercial and artistic uses up to the mid 1980s.
Johnston, Sean F.
core +1 more source
Concept talk cannot be avoided [PDF]
, 2010 Distinct systems for representing concepts as prototypes, exemplars, and theories are closely integrated in the mind, and the notion of concept is required as a framework for exploring this integration.
Barsalou +4 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source