Results 31 to 40 of about 1,297,544 (271)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Trusting Computations: a Mechanized Proof from Partial Differential Equations to Actual Program [PDF]
, 2014 Computer programs may go wrong due to exceptional behaviors, out-of-bound array accesses, or simply coding errors. Thus, they cannot be blindly trusted.
Boldo, Sylvie +5 more
core +5 more sources
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Phrenologizing Opera Singers: The Scientific “Proofs of Musical Genius” [PDF]
19th-Century Music, 2015 In some descriptions from the first half of the nineteenth century, scientific categories are used syncretically to explain opera singers' talents, including their innate and acquired dispositions, and their effects on audiences. Phrenology sought to read on the surface of skulls the developments of cerebral zones that corresponded to various instincts,
openaire +3 more sources
Medtronic v. Boston Scientific: Allocating the Burden of Proof in Declaratory Judgment Actions for Patent Non-Infringement [PDF]
, 2013 This commentary previews an upcoming Supreme Court case, Medtronic, Inc. v. Boston Scientific Corporation, in which the Court will decide which party bears the burden of proof in a declaratory judgment action for patent non ...
Strange, Brianna
core +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
RECONSTRUCTION OF SCIENTIFIC INVESTIGATION IN INDONESIA
Jurnal Pembaharuan Hukum, 2018 The purpose of this study is to analyze the process of scientific investigation, the empowerment of scientific investigation by investigators, obstacles faced and finding scientific investigation based ideal of justice.
Teguh Prihmono
doaj +1 more source
Mathematical Proofs and Scientific Discovery
, 2020 The idea that science can be automated is so deeply related to the view that the method of mathematics is the axiomatic method, that confuting the claim that mathematical knowledge can be extended by means of the axiomatic method is almost equivalent to confuting the claim that science can be automated.
openaire +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
F1000Research, 2016 Trust in scientific research is diminished by evidence that data are being manipulated. Outcome switching, data dredging and selective publication are some of the problems that undermine the integrity of published research.
Greg Irving, John Holden
doaj +1 more source