Results 51 to 60 of about 204,003 (303)

Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Closing Doors and Opening Gates: Professor Ruggles Gates, “Race Crossing” Research, and the Strange Survival of Scientific Racism in Post-war Australia

HoST
In 1958, botanist-biologist Professor Reginald Gates conducted biometric and anthropometric “race crossing” studies on populations spanning Australia and Papua New Guinea.
Brown Robert
doaj   +1 more source

Reviewing research evidence and the case of participation in sport and physical recreation by black and minority ethnic communities [PDF]

, 2014
The paper addresses the implications of using the process of systematic review in the many areas of leisure where there is a dearth of material that would be admitted into conventional Cochrane Reviews.
Amara M., Back L., Bains J., Barlow M., Bradbury S., Burdsey D. C., Carrington B., Coalter F., Connolly P., Council of Europe, Countryside Access and Activities Network, Crabbe T., Department of Communities and Local Government, Finney N., Hylton K., Hylton K., Hylton K., Jonathan Long, Jones H., Kevin Hylton, King C., Lather P., Long J., Lorde A., Mcdonald I., Morse J., Omi M., ONS, Pawson R., Rees P., Rowe N., Scott Porter Research, Sport England, Sport England, Sport England, Sport England, Sport England, Sports Council, Sportscotland, Weiss C.   +39 more
core   +1 more source

Photosensitizing Lipid Nanoparticles for Ferroptosis‐Enhanced Photodynamic Cancer Therapy via GPX4 Silencing

Advanced Healthcare Materials, EarlyView.
Photosensitizing lipid nanoparticles (PLNPs) are engineered by incorporating cholesterol–PEG–pheophorbide a into MC3‐based LNPs and encapsulating GPX4‐targeting siRNA. Upon light activation, PLNPs generate reactive oxygen species (ROS) while silencing GPX4 to induce ferroptosis.
Ga‐Hyun Bae, Seungyong Shin, Joo Dong Park, Eun‐Young Koh, Seunghyo Ko, Jieun Han, Chun Gown Park, Dong‐Hyun Kim, Kun Na, Wooram Park   +9 more
wiley   +1 more source

Racialization Without Racism in Scholarship on Old Age

Swiss Journal of Sociology, 2020
Population aging and international migration have propelled the aging of ethno-cultural minorities to the forefront of social scientific inquiries. Examining how scholarship on old age makes sense of ethnicity and race has become relevant.
Torres Sandra
doaj   +1 more source

The Impact of the Criminalization of HIV Non-Disclosure on the Health and Human Rights of “Black” Communities [PDF]

, 2013
The criminalization of HIV non-disclosure has become a hot topic for discussion and debate amongst human rights advocates, HIV/AIDS service providers, and people infected and affected by HIV/AIDS.
Wilson, Ciann L.
core   +3 more sources

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Indelible Race Memories and Subliminal Epigenetics in Octavia Butler’s Kindred [PDF]

Intersections, 2018
Octavia E. Butler’s Kindred highlights complexities beyond those related to a tale of time-travel and a painful slave narrative. It allows us to reimagine definitions of “race memory” and “trauma” along the lines of genetic ancestry that is explored ...
Dutta, Suchismita
doaj