Results 21 to 30 of about 12,648 (296)

Scientific Realism and Metaphysics

open access: yesRatio, 2005
The tendency to take scientific realism to be a richer metaphysical view than it ought to be stems from the fact that there are two ways in which we can conceive of reality. The first is to conceive of reality as comprising all facts and the other is to conceive of it as comprising all and only fundamental facts.
openaire   +2 more sources

Does Scientific Realism Beg the Question?

open access: yesInformal Logic, 1996
In a series of influential articles, the anti-realist Arthur Fine has repeatedly charged that a certain very popular argument for scientific realism, that only realism can explain the instrumental success of science, begs the question. I argue that on no
Geoffrey Gorham
doaj   +1 more source

Realism about What? Unobservable Entities and the Metaphysics of Modality

open access: yesFilosofia Unisinos, 2016
Most philosophers who advocate Scientific Realism (SR) endorse also Modal Realism (MR), i.e., assume commitments with objective modality. However, the precise relationship between these positions has been scarcely explored.
Bruno Borge
doaj   +1 more source

Myths and Falsehoods about Scientific Realism

open access: yesArtefactos, 2018
Selective realist projects seek to strengthen scientific realism, but influential reactions (from anti-realist as well as realist camps) regard selectivist achievements as problematic and misguided developments, because -the story goes- those ...
Alberto CORDERO
doaj   +1 more source

Cerebrospinal Fluid Liquid Biopsy Enables Targeted Therapy Without Tissue Diagnosis in Pediatric Low‐Grade Gliomas With BRAF V600E Mutation

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan   +5 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Rôle et légitimité de la notion de schème conceptuel dans le réalisme de Quine

open access: yesPhilosophia Scientiæ, 2009
Quine’s mathematical and scientific realism is based upon the supposition of an all-inclusive conceptual scheme, presented as a continuation of the elementary concepts and truths acquired during the process of language learning.
Xavier Sabatier
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

“Miraculous realism” in Zaitsev’s, Shmelev’s, Bunin’s prose (in context of magical realism, fantastic realism, mystical realism, spiritual realism, etc.)

open access: yesRUDN Journal of Studies in Literature and Journalism, 2019
There are many terms that denote the invasion of the inexplicable into a realistic narrative, such as: magical realism, fantastic realism, mystical realism, spiritual realism, transcendental realism, metaphysical realism, Christian realism, etc.
Vitaliy Alexandrovich Gavrikov
doaj   +1 more source

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