Results 41 to 50 of about 5,759,774 (291)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
The Argument from Underconsideration and Relative Realism [PDF]
, 2013 In this paper, through a critical examination of Wray’s version of the argument from underconsideration against scientific realism, I articulate a modest version of scientific realism.
Mizrahi, Moti
core
, 2011 According to causal realism, causation is a fundamental feature of the world, consisting in the fact that the properties that there are in the world, including notably the fundamental physical ones, are dispositions or powers to produce certain effects ...
Michael Esfeld, Esfeld, Michael
core +1 more source
Rôle et légitimité de la notion de schème conceptuel dans le réalisme de Quine
Philosophia Scientiæ, 2009 Quine’s mathematical and scientific realism is based upon the supposition of an all-inclusive conceptual scheme, presented as a continuation of the elementary concepts and truths acquired during the process of language learning.
Xavier Sabatier
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Scientific Realism and the God's Eye Point of View [PDF]
, 2003 According to scientific realism, the aim of science is to discover the truth about both observable and unobservable aspects of the mind-independent, objective reality, which we inhabit. It has been objected by Putnam and others that such a metaphysically
Sankey, Howard
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Realism and Theories of Truth [PDF]
, 2017 The topic of truth has long been thought to be connected to scientific realism and its opposition. In this chapter, I discuss the various ways that truth might be related to realism.
Asay, Jamin, Asay, JF
core +1 more source
Practical Realism: Against Standard Scientific Realism and Anti-Realism
Studia Philosophica Estonica, 2012 In this paper, the elaboration of the concept of practical realist philosophy of science which began in the author's previous papers is continued.
Rein Vihalemm
doaj
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source