Results 51 to 60 of about 253,424 (250)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Scientific Realism and Primordial Cosmology [PDF]
, 2016 We discuss scientific realism from the perspective of modern cosmology, especially primordial cosmology: i.e. the cosmological investigation of the very early universe.
Azhar, Feraz, Butterfield, Jeremy
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Structural realism versus deployment realism: A comparative evaluation [PDF]
, 2016 In this paper I challenge and adjudicate between the two positions that have come to prominence in the scientific realism debate: deployment realism and structural realism.
Lyons, Timothy D.
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Practical Realism: Against Standard Scientific Realism and Anti-Realism
Studia Philosophica Estonica, 2012 In this paper, the elaboration of the concept of practical realist philosophy of science which began in the author's previous papers is continued.
Rein Vihalemm
doaj
RUDN Journal of Studies in Literature and Journalism, 2019 There are many terms that denote the invasion of the inexplicable into a realistic narrative, such as: magical realism, fantastic realism, mystical realism, spiritual realism, transcendental realism, metaphysical realism, Christian realism, etc.
Vitaliy Alexandrovich Gavrikov
doaj +1 more source
, 2016 This article endeavors to identify the strongest versions of the two primary arguments against epistemic scientific realism: the historical argument—generally dubbed “the pessimistic meta-induction”—and the argument from underdetermination.
Lyons, Timothy D.
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Realism and Theories of Truth [PDF]
, 2018 The topic of truth has long been thought to be connected to scientific realism and its opposition. In this essay, I discuss the various ways that truth might be related to realism.
Asay, Jamin
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