Results 71 to 80 of about 5,759,774 (291)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Causal Knowledge as a Resource for Selective Scientific Realism
, 2018 The main challenge for selective scientific realism is to find reliable and prospectively applicable criteria on which parts of scientific theories one should be realist about.
Egg, Matthias
core +1 more source
Revisiting Poincaré’s conventionalism and anti-realism
Filosofia Unisinos, 2021 Poincaré’s philosophical conception and his contribution to the Philosophy of Science has been reconsidered since the recent rise of structural realism (SR), 18 years ago.
Susana Lucero
doaj
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Scientific Realism without the Wave Function
, 2019 Scientific realism assumes that our best scientific theories can be regarded as (approximately) true. Quantum mechanics has long been regarded as at odds with scientific realism. It is now known that this is not true. However, scientific realists usually
Allori, Valia, Valia Allori
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Ontic structural realism and the interpretation of quantum mechanics [PDF]
, 2012 This paper argues that ontic structural realism (OSR) faces a dilemma: either it remains on the general level of realism with respect to the structure of a given theory, but then it is, like epistemic structural realism, only a partial realism; or it is ...
Esfeld, Michael
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Scientific Realism and Chemistry
, 2017 Chemistry, the science of substances and their transformations with roots in antiquity, provides as rich a source as any of the claims about what is not directly observable in the light of ideas reflecting both constancy and change.
Needham, Paul,, Paul Needham
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Realizm i idealizm: struktura problemu (Realism and Idealism: the Structure of the Debate) [PDF]
Analiza i Egzystencja, 2009 The aim of the article is to systematize fundamental concepts involved in the philosophical debate on realism and idealism. In the first (historical) part distinction between appearance and reality (which has its roots in ancient philosophy) is presented
Stanisław Judycki
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