Results 71 to 80 of about 253,424 (250)
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Astroparticle physics, a constructive empiricist account
Science & Philosophy, 2019 Astroparticle physics is an interdisciplinary field embracing astronomy, astrophysics and particle physics. In a recent paper on this topic (2012), Brigitte Falkenburg defended that only scientific realism can make sense of it and that realist beliefs ...
Alessio Gava
doaj +1 more source
The Unificatory Power of Scientific Realism [PDF]
, 2017 The no-miracles argument (Putnam, 1975) holds that science is successful because successful theories are (approximately) true. Frost-Arnold (2010) objects that this argument is unacceptable because it generates neither new predictions nor unifications ...
Park, Seungbae
core +2 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Revisiting Poincaré’s conventionalism and anti-realism
Filosofia Unisinos, 2021 Poincaré’s philosophical conception and his contribution to the Philosophy of Science has been reconsidered since the recent rise of structural realism (SR), 18 years ago.
Susana Lucero
doaj
Naive realism and the scientific narration of perception [PDF]
, 2018 Naive realism is a widely debated topic in the philosophy of the mind. In this article I will review the theses of naive realism through the works of one of the most influential philosophers who supported and developed them, Michael Martin.
Bucci, Andrea
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Scientific Realism without Rigid Designation in Kant's Analogies [PDF]
, 2016 In Kant, Science, and Human Nature, Robert Hanna argues against a version of scientific realism founded on the Kripke/Putnam theory of reference, and defends a Kant-inspired manifest realism in its place. I reject Kriple/Putnam for different reasons than
Landy, David
core
Scientific Realism Made Effective [PDF]
, 2017 I argue that a common philosophical approach to the interpretation of physical theories -- particularly quantum field theories -- has led philosophers astray.
Williams, Porter
core +2 more sources