Results 91 to 100 of about 253,424 (250)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Scientific Realism and the Future Development of Science [PDF]
, 2019 Nickles (2016, 2017, forthcoming) raises many original objections against scientific realism. One of them holds that scientific realism originates from the end of history illusion.
Park, Seungbae
core +3 more sources
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Scientific Realism without the Wave-Function: An Example of Naturalized Quantum Metaphysics [PDF]
, 2019 Scientific realism is the view that our best scientific theories can be regarded as (approximately) true. This is connected with the view that science, physics in particular, and metaphysics could (and should) inform one another: on the one hand, science
Allori, Valia
core +1 more source
The Role of Existential Quantification in Scientific Realism [PDF]
, 2017 Scientific realism holds that the terms in our scientific theories refer and that we should believe in their existence. This presupposes a certain understanding of quantification, namely that it is ontologically committing, which I challenge in this ...
Finn, Suki
core +2 more sources
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Pragmatist Perspectives on Theological and Religious Realism [PDF]
, 2014 This essay first applies the general issue of realism vs. antirealism to theology and the philosophy of religion, distinguishing between several different ”levels’ of the realism dispute in this context.
Pihlström, Sami
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Subject and Object in Scientific Realism [PDF]
, 2017 In this paper, I explore the relationship between the subject and the object from the perspective of scientific realism. I first characterize the scientific realist position that I adopt.
Sankey, Howard
core
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source