Results 81 to 90 of about 253,424 (250)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Realizm i idealizm: struktura problemu (Realism and Idealism: the Structure of the Debate) [PDF]
Analiza i Egzystencja, 2009 The aim of the article is to systematize fundamental concepts involved in the philosophical debate on realism and idealism. In the first (historical) part distinction between appearance and reality (which has its roots in ancient philosophy) is presented
Stanisław Judycki
doaj
Why Quantum Theory is Possibly Wrong [PDF]
, 2010 Quantum theory is a tremendously successful physical theory, but nevertheless suffers from two serious problems: the measurement problem and the problem of interpretational underdetermination.
B.D. Espagnat +7 more
core +3 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Machine Learning and the Future of Realism [PDF]
, 2017 The preceding three decades have seen the emergence, rise, and proliferation of machine learning (ML). From half-recognised beginnings in perceptrons, neural nets, and decision trees, algorithms that extract correlations (that is, patterns) from a set of
Hooker, Cliff, Hooker, Giles
core +2 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Kitcher, Correspondence, and Success [PDF]
, 2004 Concerned that deflationary theories of truth threaten his scientific realism, Philip Kitcher has constructed an argument that scientific success establishes not only the truth of crucial scientific beliefs but also their *correspondence* truth.
Whitcomb, Dennis
core
Scientific realism as a challenge to economics (and vice versa) [PDF]
, 2011 The implications of scientific realism in regard to economics depend on what one takes scientific realism to mean and on whether one lets its contents to depend on the peculiar characteristics of the discipline of economics.
Mäki, Uskali
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
On the Prospects for a Unified Theory of Physics: A Belated Response to Stephen Hawking
Science & PhilosophyAs theoretical physicist Stephen Hawking speculated on the prospects for a complete, unified theory in his 1988 book, A Brief History of Time, he appeared to embrace both scientific realism and instrumentalism.
Leemon Benton McHenry
doaj +1 more source