Results 141 to 150 of about 1,279,520 (308)

Design and hydrodynamic analysis of subsea development automatic placement devices

Frontiers in Mechanical Engineering
In response to the problems of low efficiency and safety hazards in traditional subsea pipeline intersection isolation release operations, this study designs a new type of automatic deployment device for subsea oil and gas pipeline intersection isolation,
Jun Han, Jun Han, Jun Han, Zai-Ming He, Zai-Ming He, Zai-Ming He, Ling Ma, Ling Ma, Ling Ma, Xiu-Feng Li, Xiu-Feng Li, Xiu-Feng Li, Jiang-Long Wan, Jiang-Long Wan, Jiang-Long Wan   +14 more
doaj   +1 more source

The Roles of Research at Universities and Public Labs in Economic Catch-up [PDF]

We draw upon historical evidence from several countries and contemporary studies of national innovation systems to argue that indigenous systems of academic training and public research have been in the past important elements of the institutional ...
Richard R. Nelson, Roberto Mazzoleni
core  

Practical aspects of the technical and technological development level determining the machine-building enterprise [PDF]

, 2014
The aim of the article. The aim of the article is to determine the technical-technological development level of the machine-building enterprise on the basis of the proposed methodological approach. The results of the analysis. Low innovation activity of
O.G. Shevliuga
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Challenges of Teaching Science to Address Global Sustainability [PDF]

, 2015
For a liveable condition in this post- industrial era, it would depend on our ability to understand and use the science and technology advancement in a responsible manner.
Halim, L. (Lilia)
core  

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Jet Injection of Naked mRNA Encoding the RBD of the SARS-CoV-2 Spike Protein Induces a High Level of a Specific Immune Response in Mice

Vaccines
Background: Although mRNA vaccines encapsulated in lipid nanoparticles (LNPs) have demonstrated a safety profile with minimal serious adverse events in clinical trials, there is opportunity to further reduce mRNA reactogenicity.
Denis N. Kisakov, Larisa I. Karpenko, Lyubov A. Kisakova, Sergey V. Sharabrin, Mariya B. Borgoyakova, Ekaterina V. Starostina, Oleg S. Taranov, Elena K. Ivleva, Oleg V. Pyankov, Anna V. Zaykovskaya, Elena V. Dmitrienko, Vladimir A. Yakovlev, Elena V. Tigeeva, Irina Alekseevna Bauer, Svetlana I. Krasnikova, Nadezhda B. Rudometova, Andrey P. Rudometov, Artemiy A. Sergeev, Alexander A. Ilyichev   +18 more
doaj   +1 more source

Scientific and Technological Innovation and Enterprise Sustainable Development Strategy Research [PDF]

Advance in Sustainability, 2021
openaire   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Helicopter human factors research [PDF]

Helicopter flight is among the most demanding of all human-machine integrations. The inherent manual control complexities of rotorcraft are made even more challenging by the small margin for error created in certain operations, such as nap-of-the-Earth ...
Hart, Sandra G., Nagel, David C.
core   +1 more source