Results 131 to 140 of about 1,279,520 (308)
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Role of Research in Manufacturing and Processing Asadded Value to the Economy [PDF]
The aim of this paper is to cast some shadow on the policies of research with regards to socio-economic development of the nation. It will high light some points for taking the results of scientific and technological studies from the research level to ...
Abdelsalam, Tagelsir Mustafa
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The Brazilian investment in science and technology
Brazilian Journal of Medical and Biological Research, 2001 An analysis of Brazilian federal expenditures in science and technology is presented is this study. The 1990-1999 data were compiled from records provided by two federal agencies (MCT and CNPq) responsible for managing most of the national budget related
Pinheiro-Machado R., de Oliveira P.L.
doaj
Traces of prior art. An analysis of non-patent references found in patent documents. [PDF]
Research in the area of innovation has pointed out the relevance of conceiving innovation as processes in which a multitude of actors and a variety of interactions play a role.
Callaert, J +4 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Bio-organic Alternatives for Propagation of Psidium Guajava (L.) through Stem Cuttings
Agrisost, 2017 The aim of this study was to use different stimulators for guajabo propagation using stem cuttings in semi-controlled conditions, on "La Nueva Esperanza" farm, run by "Renato Guitart" Strengthened Cooperative of Credits and Services, in the municipality ...
Pedro López Labarta +3 more
doaj +2 more sources
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Innovation effects of science-related technological opportunities: Theoretical considerations and empirical findings for firms in the German manufacturing industry [PDF]
, 2002 This paper investigates the innovation effects of science-related technological opportunities. Against the background of theoretical considerations about the interrelation of innovation and the adaptation of external (knowledge) resources, the impacts of
Becker, Wolfgang, Peters, Jürgen
core
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source