Results 111 to 120 of about 1,279,520 (308)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The relationship between intra- and intergenerational ecological justice. Determinants of goal conflicts and synergies in sustainability policy [PDF]
The guiding principle of sustainability is widely accepted in today´s international policies. The principle contains two seperate objectives of justice with regard to the conservation and use of ecosystems and their services: (1) global justice between ...
Stefan Baumgärtner, Stefanie Glotzbach
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Commercialisation of research results – cooperation between science and business [PDF]
, 2013 When analysing the term commercialisation one should answer the crucial question: what mechanisms govern commercialisation of knowledge and technology as well as which resources and sources determine it. The article presents a theoretical deliberation
Trzmielak, Dariusz
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Scientific ReportsAdding organic amendments to agricultural systems as sustainable practices is one of the most important stages toward creating a more sustainable and environmentally friendly food system.
Doaa A. Goda +3 more
doaj +1 more source
A Statement on the Appropriate Role for Research and Development in Climate Policy [PDF]
This statement is issued by a group of economists and scientists which met at Stanford University on October 18, 2008 to discuss the role of research and development (R&D) in developing effective policies for addressing the adverse potential consequences
Arrow, Kenneth J. +9 more
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
The Patenting Behavior of Academic Founders [PDF]
This study explores why academic entrepreneurs patent their inventions before and after creating a firm. Drawing on start-up data combined with patent data, we specifically examine the impact of five, relatively under-researched factors (scientific field,
Schmidt, Arne +2 more
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Advancing organic and low-input food. QLIF Integrated Research Project [PDF]
, 2009 The Integrated Project “Improving quality and safety and reduction of costs in the European organic and low input supply chains” (QLIF) was funded by the European Commission under the 6th Framework Programme for Research and Technological Development ...
Niggli, Urs
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