Results 91 to 100 of about 1,279,520 (308)

SCIENTIFIC-TECHNOLOGICAL PROGRESS OF UZBEKISTAN: PROBLEMS AND PROSPECTS [PDF]

The article considers aspects concerning effective coordination of scientific-technological development in Uzbekistan. In the conditions of new economy, insufficient development and use of innovations in the domestic economy will contain the rate of ...
Azimov, Abror
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Enhanced voltage generation in microbial fuel cells (MFCs) using bacterial isolates from seawater and industrial wastewater

Microbial Cell Factories
Background This study investigates the potential of microbial fuel cells (MFCs) for bioelectricity generation from seawater and wastewater sources. It focuses on the isolation, identification, and statistical optimization of electrogenic bacteria from ...
Ghada E. Hegazy, Nadia A. Soliman, Yasser R. Abdel-Fattah, Tarek H. Taha   +3 more
doaj   +1 more source

Innovation Effects of Science-Related Technological Opportunities - Theoretical Considerations and Empirical Findings for Firms in the German Manufacturing Industry - [PDF]

This paper investigates the innovation effects of science-related technological opportunities. Against the background of theoretical considerations about the interrelation of innovation and the adaptation of external (knowledge) resources, the impacts of
Juergen Peters, Wolfgang Becker
core  

The Seven Sources of Information Technology and Its Role in the Development of Scientific Research

Al-Kitab Journal for Pure Sciences, 2023
With the rapid technological development in various walks of life, Information Technology (IT) resources play an exceptional and key role in the advancement of the field of scientific research, as data sources and electronic content E-Data & E-Content transfer scientific and research resources in a digital (electronic) format to achieve ...
openaire   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Profile of Nursing research groups of the National Council for Scientific and Technological Development

Rev Rene, 2014
Nursing has been developing in the research field, therefore, it is important to be inserted into a research group of the National Council for Scientific and Technological Development, a funding agency that supports studies and strengthens the knowledge.
Costa, Andréia Cristina Barbosa, Chaves, Erika de Cássia Lopes, Terra, Fábio de Souza, Monteiro, Lidiane Aparecida   +3 more
openaire   +4 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Research Work as a Factor of Successful Development [PDF]

Efficient innovation policy and adequate investment in scientific research are a starting point for the sustainable development of a country. A prerequisite for sustainable development in any country is the development of indigenous scientific and ...
Babic, V.
core   +1 more source